Ambroxol for the treatment of chronic pain

• US 20030171391A1
• Filed: 01/21/2003
• Published: 09/11/2003
• Est. Priority Date: 01/25/2002
• Status: Abandoned Application

• Current Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Klinder, Klaus, Gaida, Wolfram, Weiser, Thomas
• Application Number:
  US10/348,283
• Publication Number:
  US 20030171391A1
• Time in Patent Office: Days
• US Class Current: 514/282
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61K 9/02 Suppositories; Bougies; Bases therefor; Ovulesapparatus for making A61J3/08; devices for introducing into the body A61M31/00
• CPC Class Codes: A61K 9/2059 Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
• CPC Class Codes: A61K 9/2826 Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
• CPC Class Codes: A61K 9/4866 Organic macromolecular compounds

Abstract

The invention relates to the use of ambroxol and the pharmacologically acceptable salts thereof for preparing a pharmaceutical composition for the treatment of diseases which are based on a powerful activation of voltage-dependent sodium channels, particularly for the treatment of chronic pain.

Claims

1. A method for teating diseases or conditions which are based on a powerful activation of voltage-dependent sodium channels, which method comprises administering to a host suffering from such a disease a therapeutically effective amount of ambroxol or a pharmacologically acceptable salt thereof.

2. The method of claim 1 wherein the disease or condition is based on the activation of tetrodotoxin-resistant sodium channels.

3. The method of claim 1 wherein the disease or condition to be treated is chronic pain.

4. The method of claim 1 wherein the disease or condition to be treated is a cerebral excitotoxicity-induced disorder.

5. The method of claim 1 wherein the disease or condition to be treated is a cardiac arrhythmia.

6. The method of claim 1, 2, 3, 4 or 5 wherein there is further administered an active substance selected from the group consisting of the analgesics, anticonvulsants, neuroprotective substances and antiarrhythmics.

7. The method of claim 1, 2, 3, 4 or 5 wherein there is further administered an active substance selected from the group consisting of the opiates, non-steroidal analgesics, gabapentine and antidepressants and alpha-adrenergic agonists.