Internal biochemical sensing device
First Claim
1. A compact and portable biosensing device for detecting an analyte from within a patient'"'"'s body, comprising:
- a. a biosensing element including a biosensing material;
b. an elongated transmitting member having a first end and a second end, and being optically aligned with the biosensing element at the first end; and
c. a portable information analyzer connected to the second end of the elongated transmitting member and sized and configured to be easily carried by the patient.
2 Assignments
0 Petitions
Accused Products
Abstract
A biosensing device for detecting biological analytes, and methods of use and manufacture, are disclosed. The device includes a biosensing element that can remain implanted for extended periods of time. The biosensing element is connected to an optical fiber terminating outside of the body. The optical fiber is also connected to an information analyzer. The information analyzer directs light through the optical fiber into the biosensing element. The light excites fluorophores, created by a chemical reaction between analytes and biosensing material within the biosensing element. Emitted fluorescent light is redirected through the optical fiber to the information analyzer. Optical gratings within the filtering member of the information analyzer selectively deflect fluorescent emissions into a cladding layer. Detectors attached to the cladding layer detect the deflected fluorescent emissions and, according to their determined wavelength, report the presence or quantity of specific analytes to the patient on an external display.
-
Citations
47 Claims
-
1. A compact and portable biosensing device for detecting an analyte from within a patient'"'"'s body, comprising:
-
a. a biosensing element including a biosensing material;
b. an elongated transmitting member having a first end and a second end, and being optically aligned with the biosensing element at the first end; and
c. a portable information analyzer connected to the second end of the elongated transmitting member and sized and configured to be easily carried by the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
-
-
12. An information analyzer for sensing an analyte detected from within a patient'"'"'s body, comprising:
-
a. an elongated filtering member configured to propagate light and having a cladding layer along its length and having a first end and a second end;
b. the elongated filtering member further comprising a wavelength specific grating region configured to deflect a portion of the propagated light having the specific wavelength into the cladding layer;
c. a connector operatively connected to the first end of the elongated filtering member and adapted to receive an optical fiber and form an optical connection therewith;
d. a light source operatively connected to the second end of the elongated filtering member and configured to direct light therethrough; and
e. a processor operatively connected to the cladding layer for detecting the deflected light. - View Dependent Claims (13, 14)
-
-
15. A method of using a compact and portable biosensing device, comprising:
-
a. inserting a biosensing element and a first end of an elongated transmitting member into a patient'"'"'s body such that the first end of the elongated transmitting member is optically aligned with the biosensing element, and a second end of the elongated transmitting member remains outside of the patient'"'"'s body;
b. optically coupling the second end of the elongated transmitting member to a portable information analyzer;
c. directing light from a light source through an elongated filtering member within the information analyzer and through the elongated transmitting member to the biosensing element;
d. directing fluorescent energy from the biosensing element and activated by the directed light through the elongated transmitting member and through at least a part of the elongated filtering member;
e. deflecting at least a portion of the fluorescent energy to a cladding layer adjacent to the elongated filtering member; and
f. detecting the deflected fluorescent energy. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
-
-
23. An adaptive system of biosensors for sensing a plurality of analytes, comprising:
-
a. a first biosensor device comprising a first biosensing element and a first elongated transmitting member;
b. a second biosensor device comprising second biosensing element and a second elongated transmitting member;
c. a first end of each of the first and second elongated transmitting members being optically connectable to a portable information analyzer;
d. wherein the first biosensing element contains a first biosensing material that is different from a second biosensing material contained within the second biosensing element, and the first and second biosensing materials react with different ones of the plurality of analytes. - View Dependent Claims (24, 25, 26)
-
-
27. A method of manufacturing a compact and portable biosensing device, comprising:
-
a. encapsulating a biosensing material within a region substantially adjacent to a first end of an elongated transmitting member by attaching a containment matrix to the first end of the elongated transmitting member such that it surrounds the biosensing material;
b. providing a connector that will align a second end of the elongated transmitting member with a first end of an elongated filtering member such that they are optically connected;
c. creating a wavelength specific optical grating in a portion of the elongated filtering member; and
d. connecting a light detector to the elongated filtering member adjacent to the wavelength specific optical grating. - View Dependent Claims (28, 29, 30, 31)
-
-
32. A compact and portable biosensing device for detecting an analyte from within a patient'"'"'s body, comprising:
-
a. a biosensing element for implantation in a patient'"'"'s body including one or more biosensing materials for selective interaction with an analyte, wherein the binding of the analyte to the biosensing material results in a detectable state change within the biosensing element;
b. a transmitting member having a first end and a second end and a transmitting member outer surface, and the first end being implanted within a patient'"'"'s body and in proximity with the biosensing element; and
c. an information analyzer connected to the second end of the transmitting member configured for location outside the patient'"'"'s body. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39)
-
-
40. A compact and portable biosensing device for detecting an analyte from within a patient'"'"'s body, comprising:
-
a. a biosensing element for implantation in a patient'"'"'s body including one or more biosensing materials for selective interaction with an analyte, wherein the binding of the analyte to the biosensing material results in a detectable state change within the biosensing element, and wherein the biosensing material is enclosed in a containment matrix permeable to the analyte;
b. a transmitting member having a first end and a second end and a transmitting member outer surface, wherein at least a portion of the transmitting member outer surface is coated to promote cell adhesion, and the first end being implanted within a patient'"'"'s body and in contact with the biosensing element; and
c. an information analyzer connected to the second end of the transmitting member configured for location outside the patient'"'"'s body.
-
-
41. The method of manufacturing a component for use in a biosensing device for detecting one or more analytes, including:
-
a. providing a transmitting member having a first end and a second end, the second end being configured for operably coupling to an information analyzer;
b. applying a biosensing element having one or more biosensing materials to the transmitting member first end; and
c. applying a containment matrix to the transmitting member first end wherein the containment matrix substantially surrounds the biosensing materials and wherein the containment matrix is permeable to an analyte to be detected. - View Dependent Claims (42, 43, 44, 45, 46, 47)
-
Specification