Closed-loop drug delivery system
First Claim
1. A drug delivery system capable of delivering an effective amount of a drug to a subject, comprising:
- a delivery pump having a chamber capable of housing at least one drug;
a delivery conduit connected to the pump and adapted to extend into a tissue site in the subject, the delivery conduit being effective to deliver the drug from a distal end thereof to the tissue site;
a sensor, implantable within a subject, and capable of providing a sensor output signal representative of a sensed biochemical parameter; and
a control unit in communication with the sensor and the pump, wherein the control unit to receives the sensor output signal and communicates a delivery signal to the pump to deliver the drug at a rate and for a duration effective to achieve a desired biochemical parameter within a predetermined range.
1 Assignment
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Accused Products
Abstract
A delivery system for a drug or bioactive agent includes an implantable pump and a delivery conduit that may be implanted in an organ or other tissue (e.g., the central or the peripheral nervous system) of a subject. A sensor is also implanted, and a controller unit receives the sensor output and directs drug delivery from within the patient pump accordingly. The sensor directly measures a primary biochemical material or state in the tissue or organ system, and the monitoring unit effects closed loop feedback control of the pump to achieve a desired end. The end may be the regulation of metabolism or maintenance of a stable metabolic or other state, or may be treatment regimen, e.g., by delivery of a dosage level or distribution of a drug in specific brain or nervous an system tissue. The sensed material may be the agent itself, a metabolite, or a related native material, tissue state or condition.
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Citations
19 Claims
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1. A drug delivery system capable of delivering an effective amount of a drug to a subject, comprising:
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a delivery pump having a chamber capable of housing at least one drug;
a delivery conduit connected to the pump and adapted to extend into a tissue site in the subject, the delivery conduit being effective to deliver the drug from a distal end thereof to the tissue site;
a sensor, implantable within a subject, and capable of providing a sensor output signal representative of a sensed biochemical parameter; and
a control unit in communication with the sensor and the pump, wherein the control unit to receives the sensor output signal and communicates a delivery signal to the pump to deliver the drug at a rate and for a duration effective to achieve a desired biochemical parameter within a predetermined range. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of drug treatment, comprising the steps of:
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providing an infusion pump implantable at a site in a subject, wherein the pump includes a housing having a chamber for containing one or more drugs and being operable to deliver the drug from the infusion pump;
providing a delivery pathway from the infusion pump to a target tissue site within the subject; and
providing a sensor configured for implantation at a sensing location in the subject, wherein the sensor is adapted to detect a biochemical parameter or event at the sensing location and to produce an output signal indicative thereof; and
providing a control unit, implantable at a site in a subject, wherein the control unit is able to receive the output signal from the sensor and wherein the control unit is in communication with the infusion pump, wherein the control unit controls drug delivery from the infusion pump, responding to data provided by the output signal in a closed loop feedback cycle to regulate delivery of the drug from the infusion pump so as to release the drug at the target site to maintain the sensed biochemical parameter or event within a predetermined range. - View Dependent Claims (15, 16, 17, 18, 19)
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Specification