Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
First Claim
Patent Images
1. A method for distributing a pharmaceutical agent in the adventitial tissue of a living vertebrate host, said method comprising:
- positioning a microneedle through the wall of a blood vessel so that an aperture of the microneedle is positioned in a perivascular space surrounding the blood vessel; and
delivering an amount of the pharmaceutical agent into the perivascular space so that the agent distributes substantially completely circumferentially through adventitial tissue surrounding the blood vessel at the site of the microneedle.
2 Assignments
0 Petitions
Accused Products
Abstract
Methods and kits for delivering pharmaceutical agents to the adventitia surrounding a blood vessel utilize a catheter having a microneedle. The microneedle is positioned in the perivascular space and delivers an amount of pharmaceutical agent sufficient to circumferentially permeate around the blood vessel and, in many cases, extend longitudinally along the blood vessel and in some cases to the adventitia surrounding other blood vessels.
84 Citations
43 Claims
-
1. A method for distributing a pharmaceutical agent in the adventitial tissue of a living vertebrate host, said method comprising:
-
positioning a microneedle through the wall of a blood vessel so that an aperture of the microneedle is positioned in a perivascular space surrounding the blood vessel; and
delivering an amount of the pharmaceutical agent into the perivascular space so that the agent distributes substantially completely circumferentially through adventitial tissue surrounding the blood vessel at the site of the microneedle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A method for depoting a pharmaceutical agent in the adventitial tissue of a living vertebrate host'"'"'s heart, said method comprising:
-
positioning a microneedle through the wall of a coronary blood vessel so that an aperture of the microneedle is positioned in a perivascular space surrounding the blood vessel; and
delivering an amount of the pharmaceutical agent into the perivascular space so that the agent distributes within adventitial tissue surrounding the blood vessel to provide a depot of agent which is released back into the blood vessel wall over time. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
-
-
25. A method for delivering a pharmaceutical agent to a diseased treatment region in a blood vessel of a living vertebrate host, said method comprising:
-
positioning a microneedle through the wall of a blood vessel at a delivery site away from the diseased treatment region, and delivering an amount of the pharmaceutical agent through an aperture in the microneedle into a perivascular space surrounding the delivery site so that the agent distributes into adventitial tissue surrounding the diseased treatment region. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37)
-
-
38. A kit for delivering a pharmaceutical agent to a patient suffering from or at risk of vascular disease, said kit comprising:
-
a catheter having a microneedle which can be advanced from a blood vessel lumen through a wall of the blood vessel to position an aperture of the microneedle in a perivascular space surrounding the blood vessel; and
instructions for use of the catheter according to the following method;
positioning the microneedle through the wall of the blood vessel so that the aperture of the microneedle is located in a perivascular space surrounding the blood vessel; and
delivering an amount of the pharmaceutical agent into the perivascular space so that the agent distributes substantially completely circumferentially through adventitial tissue surrounding the blood vessel at the site of the microneedle.
-
-
39. A kit for delivering a pharmaceutical agent to a patient suffering from vascular disease characterized by a diseased treatment region in a blood vessel, said kit comprising:
-
a catheter having a microneedle which can be advanced from a blood vessel lumen through a wall of the blood vessel to position an aperture of the microneedle in a perivascular space surrounding the blood vessel; and
instructions for use of the catheter according to the following method;
positioning the microneedle through the wall of the blood vessel at a delivery site away from the diseased treatment region; and
delivering an amount of the pharmaceutical agent through an aperture in the microneedle into a perivascular space surrounding the delivery site so that the agent distributes into adventitial tissue surrounding the diseased treatment site.
-
-
40. A kit for delivering a pharmaceutical agent to a patient suffering from or at risk of vascular disease, said kit comprising:
-
a catheter having a microneedle which can be advanced from a blood vessel lumen through a wall of the blood vessel to position an aperture of the microneedle in a perivascular space surrounding the blood vessel; and
instructions for use of the catheter according to the following method;
positioning the microneedle through the wall of the blood vessel so that the aperture of the microneedle is located in a perivascular space surrounding the blood vessel; and
delivering an amount of a lipophilic pharmaceutical agent into the perivascular space so that the lipophilic agent distributes within the lipd-rich adventitial tissue surrounding the blood vessel to provide a depot of agent which is released back into the blood vessel wall over time.
-
- 41. The use of a catheter having a microneedle in the manufacture of apparatus for delivering pharmaceutical agents to a patient suffering from vascular disease wherein the pharmaceutical agent is delivered from a blood vessel lumen into a perivascular space surrounding the blood vessel so that the agent distributes circumferentially through adventitial tissue surrounding the blood vessel.
Specification