Convection-enhanced drug delivery device and method of use
First Claim
1. An implantable drug delivery system, comprising:
- an infusion pump including a fluid outlet;
a fluid delivery pathway effective for extending from the fluid outlet to a discharge portion positionable at a target tissue site; and
a controlled release drug assembly, said drug assembly being configured for controllably releasing drug material, and communicating with said fluid delivery pathway such that the drug material is released into said fluid delivery pathway, wherein the pump assembly is effective to deliver a carrier fluid to the fluid outlet such that the drug material released into the fluid pathway discharges at the discharge portion to treat the target tissue site.
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Accused Products
Abstract
An implantable drug delivery system includes an infusion pump assembly with a fluid outlet, a fluid delivery pathway extending from the pump outlet to a target tissue site; and a controlled release material unit positioned in the fluid delivery pathway to release a drug or bioactive material into the delivery pathway. The pump assembly delivers fluid as a high flow infusion flow in said pathway, entraining drug material released by the release unit and establishing a pressure gradient at the distal end of the pathway that results in convection-enhanced transport such that the released drug(s) or treatment material enter the target tissue site with enhanced penetration depth and/or concentration. The pump delivers a carrier fluid that may reside in an external or in an implanted reservoir, or that may be an endogenous fluid, such as plasma or CSF.
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Citations
40 Claims
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1. An implantable drug delivery system, comprising:
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an infusion pump including a fluid outlet;
a fluid delivery pathway effective for extending from the fluid outlet to a discharge portion positionable at a target tissue site; and
a controlled release drug assembly, said drug assembly being configured for controllably releasing drug material, and communicating with said fluid delivery pathway such that the drug material is released into said fluid delivery pathway, wherein the pump assembly is effective to deliver a carrier fluid to the fluid outlet such that the drug material released into the fluid pathway discharges at the discharge portion to treat the target tissue site. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method for infusing a drug into a target tissue site of a subject, the method comprising the steps of:
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providing an infusion pump assembly, wherein the pump assembly includes a carrier fluid source, wherein the infusion pump assembly is effective to convey a fluid within the pump through a fluid delivery pathway to a target tissue site;
providing a drug release assembly in communication with the fluid delivery pathway, said release assembly having at least one drug reservoir configured for controlled release of a drug into the fluid delivery pathway; and
enabling a carrier fluid to be delivered under pressure from the infusion pump assembly at a desired flow rate through the fluid delivery pathway to transport drug released by the drug release assembly to the target tissue site. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method of delivering a drug or bioactive material to target tissue such as tissue of the central nervous system (CNS), such method comprising the steps of
providing an infusion pump having an output connectable with a delivery line implantable at a target tissue site; - and
providing a controlled release drug device attachable in communication with the delivery line, such that the controlled release drug device is effective to release drug into carrier fluid pumped by the infusion pump;
thereby delivering the carrier fluid to the target tissue site with said drug, the pump being controllable to maintain an elevated delivery pressure such that the drug achieves a convectively enhanced profile in tissue at the target tissue site.
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Specification