STENTS COATED WITH FLUOROALKYL GROUPS

• US 20030171804A1
• Filed: 04/26/2000
• Published: 09/11/2003
• Est. Priority Date: 06/24/1997
• Status: Abandoned Application

• Current Assignee: Schering Ag (Merck & Co., Inc.)
• Original Assignee: Schering Ag (Merck & Co., Inc.)
• Inventors: KRAUSE, WERNER
• Application Number:
  US09/446,396
• Publication Number:
  US 20030171804A1
• Time in Patent Office: Days
• US Class Current: 623/1.46
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/0076 Chemical modification of the substrate
• CPC Class Codes: C08L 101/04 containing halogen atoms

Abstract

The invention relates to stents that consist of a stent parent substance that is coated with a carrier polymer to which are connected perfluoroalkyl chains that project from the stent surface like a brush, as well as processes for their production and their use for restenosis prophylaxis.

Claims

1. Stent, characterized in that it consists of a stent parent substance that is coated with a carrier polymer to which are connected the perfluoroalkyl chains that project from the stent surface like a brush.

2. Stent according to claim 1, wherein the stent parent substance is a metallic stent parent substance or a stent that is produced from a polymer.

3. Stent according to claim 2, wherein the metallic parent substance is a Wiktor stent, a Palmaz-Schatz stent, a Strecker stent, or a Nitinol stent.

4. Stent according to claim 1, wherein the carrier polymer is one of the following polymers:

a polyurethane derivative, a polyamino-p-xylylene derivative, a polyorganosilane, a polyvinylpyrrolidone, a polymethylmethacrylate, a polyhydroxymethylmethacrylate, a mixed polymer from N-vinylpyrrolidone and hydroxymethylmethacrylate, a polyamide, a polyacrylamide, a polyethylene, a polyethylene oxide, a polyethylene glycol, a polyester, a polypropylene oxide, a polysiloxane, a PVC derivative, a polyvinyllactam, a polyethylene terephthalate, a polysilicone, a polysaccharide, a protein, a polysulfone or a polysulfonate.

5. Stent according to claim 1, wherein fluoroalkyl-chain-containing molecules of general formula II are connected to the carrier polymer

(X—

Y—

(CF₂)_n—

Z)_m 

 

(II)

in which

X stands for a direct binding to the carrier polymer, an amino, ether, thioether, carbonyl, thiocarbonyl, sulfonyl, sulfuryl or phosphoryl group or a longer bridge to the carrier polymer, e.g., an alkyl chain, which can be interrupted by heteroatoms and/or can be substituted by heteroatoms, an amino acid, a dicarboxylic acid, a peptide, nucleotide or a sugar,

Y stands for a direct bond, an amino, ether, thioether, carbonyl, thiocarbonyl, sulfonyl, sulfuryl or phosphoryl group or a longer bridge such as, e.g., an alkyl chain, which can be interrupted by heteroatoms and/or can be substituted by heteroatoms, an amino acid, a dicarboxylic acid, a peptide, nucleotide or a sugar,

Z stands for a fluorine atom or a hydrogen atom,

n stands for a natural number that is greater than or equal to 1,

m stands for a natural number of between 1 and the number of groups that can be derivatized in the carrier polymer.

6. Process for the production of a stent according to one of the preceding claims, wherein a stent parent substance is coated with a carrier polymer, and then the surface is derivatized with perfluoroalkyl-chain-containing molecules.

7. Process according to claim 6, wherein the carrier polymer is placed on the stent parent substance by gas phase coating or plasma polymerization.

8. Surface coating, wherein perfluoroalkyl chains that project from the surface like a brush are connected to a carrier polymer.

9. Surface coating according to claim 8, wherein fluoroalkyl-chain-containing molecules of general formula II are connected to the carrier polymer:

(X—

Y—

(CF₂)<sub>n—

Z)m</sub> 

 

(II)

in which

X stands for a direct binding to the carrier polymer, an amino, ether, thioether, carbonyl, thiocarbonyl, sulfonyl, sulfuryl or phosphoryl group or a longer bridge to the carrier polymer, such as, e.g., an alkyl chain, which can be interrupted by heteroatoms and/or can be substituted by heteroatoms, an amino acid, a dicarboxylic acid, a peptide, nucleotide or a sugar,

Y stands for a direct bond, an amino, ether, thioether, carbonyl, thiocarbonyl, sulfonyl, sulfuryl or phosphoryl group or a longer bridge, such as, e.g., an alkyl chain, which can be interrupted by heteroatoms and/or can be substituted by heteroatoms, an amino acid, a dicarboxylic acid, a peptide, nucleotide or a sugar,

Z stands for a fluorine or a hydrogen atom,

n stands for a natural number that is greater than or equal to 1,

m stands for a natural number of between 1 and the number of groups that can be derivatized in the carrier polymer.