Apparatus and methods for high throughput and high-resolution assays
First Claim
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1. A device for high-resolution assays, comprising:
- a substrate that comprises at least first and second block that are configured to slide relative to each other from a first position to a second position;
at least a first separation channel defined on the first block;
at least a second separation channel defined on the second block;
wherein at the first position, the device is configured for separation of the sample along the first separation channel, whereby the sample is partially separated along the first channel, and wherein at the second position, the device is configured for separation in the second channel at least a portion of the sample which is located in a section of the first separation channel and has been partially separated in the first second channel.
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Abstract
An apparatus integrates one dimensional separation to another dimensional separation and automates the operation of the two dimensional separation. The first dimensional separation is performed in one column while the second dimensional separation is performed in multiple separation columns. The integration is achieved using a one-piece, a two-piece, or a three-piece interface.
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3 Claims
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1. A device for high-resolution assays, comprising:
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a substrate that comprises at least first and second block that are configured to slide relative to each other from a first position to a second position;
at least a first separation channel defined on the first block;
at least a second separation channel defined on the second block;
wherein at the first position, the device is configured for separation of the sample along the first separation channel, whereby the sample is partially separated along the first channel, and wherein at the second position, the device is configured for separation in the second channel at least a portion of the sample which is located in a section of the first separation channel and has been partially separated in the first second channel.
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2. A method for high-resolution assays, comprising the steps of:
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partially separating a sample in a first separation channel;
effecting separation along a second separation channel a portion of the sample which is located in a section of the first separation channel and which has been partially separated in the first separation channel.
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3. A microfluidic device, comprising:
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a reconfigurable substrate, in a first and a second configurations, a first fluid channel defined on the substrate;
a second fluid channel defined on the substrate, wherein at least a section of the first channel is in fluid communication with at least a section of the second fluid channel in the second configuration of the substrate but not in fluid communication in the first configuration of the substrate.
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Specification