Hemostatic compositions and methods for controlling bleeding
First Claim
1. A method for controlling bleeding at an active bleeding wound site of an animal, said method comprising applying a hemostatic composition to said active bleeding wound site, said hemostatic composition comprising an article comprising cellulose and a polysaccharide covalently linked to said cellulose.
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Abstract
The invention provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions typically include an article containing cellulose, e.g., cotton gauze, and a polysaccharide covalently linked to the cellulose, or a polysaccharide ionically cross-linked and in association with the article. Methods of making and using the hemostatic compositions are also provided.
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Citations
87 Claims
- 1. A method for controlling bleeding at an active bleeding wound site of an animal, said method comprising applying a hemostatic composition to said active bleeding wound site, said hemostatic composition comprising an article comprising cellulose and a polysaccharide covalently linked to said cellulose.
- 16. A method for controlling bleeding at an active bleeding wound site of an animal, said method comprising applying a hemostatic composition to said active bleeding wound site, said hemostatic composition comprising an article comprising cellulose in association with an ionically cross-linked polysaccharide.
- 27. A method for manufacturing a composition, said method comprising incubating a linking agent, a polysaccharide, and an article comprising cellulose to form a hemostatic composition comprising said polysaccharide covalently linked to said cellulose.
- 43. A method for manufacturing a composition, said method comprising incubating an article comprising cellulose in a solution of a polysaccharide and a cation to form a hemostatic composition wherein said polysaccharide is ionically cross-linked and associated with said article.
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54. A method for manufacturing a hemostatic composition, said method comprising:
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(a) mixing an aqueous phase alkaline polysaccharide solution with an organic phase stabilizing agent solution to form a mixture comprising polysaccharide spheres;
(b) incubating a cross-linking agent with said mixture to cross-link said polysaccharide spheres;
(c) isolating said cross-linked polysaccharide spheres; and
(d) coating an article comprising a sodium alginate solution with said cross-linked polysaccharide spheres. - View Dependent Claims (55, 56, 57, 58, 59, 60, 61, 62)
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63. A method for manufacturing a hemostatic composition, said method comprising:
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(a) providing an aqueous phase alkaline solution comprising dextran and sodium alginate;
(b) preparing dextran-alginate spheres from said aqueous phase alkaline solution; and
(c) incubating said dextran-alginate spheres with a linking agent to link said dextran-alginate spheres. - View Dependent Claims (64, 65, 66, 67, 68, 69, 70, 71)
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- 72. A hemostatic composition comprising an article comprising cellulose having a polysaccharide covalently linked to said cellulose.
- 81. A hemostatic composition comprising an article comprising cellulose in association with cross-linked alginate and dextran.
- 85. A hemostatic composition comprising ionically linked dextran-alginate spheres.
Specification