Endothelin antagonists and endothelin-converting enzyme inhibitors for the treatment of glaucoma
First Claim
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1. A method for treating an ocular disease or damage thereof in an animal, comprising administering to the animal, a composition containing an effective amount of an endothelin (“
- ET”
) antagonist in a pharmaceutically acceptable vehicle, wherein the ocular disease or damage is selected from the group consisting of ischemic retinopathies or optic neuropathies, commotio retinae, glaucoma, macular degeneration, retinitis pigmentosa, retinal detachment, retinal tears or holes, diabetic retinopathy, and iatrogenic retinopathy.
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Abstract
A pharmaceutical composition, containing a therapeutically effective amount of an endothelin (“ET”) antagonists and/or an endothelin-converting enzyme (“ECE”) inhibitors and a pharmaceutically acceptable carrier. The pharmaceutical composition is useful for treating normal-tension and primary open-angle glaucoma and prevents optic nerve damage and retinal ganglion cell death associated with these ocular diseases.
19 Citations
32 Claims
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1. A method for treating an ocular disease or damage thereof in an animal, comprising administering to the animal, a composition containing an effective amount of an endothelin (“
- ET”
) antagonist in a pharmaceutically acceptable vehicle, wherein the ocular disease or damage is selected from the group consisting of ischemic retinopathies or optic neuropathies, commotio retinae, glaucoma, macular degeneration, retinitis pigmentosa, retinal detachment, retinal tears or holes, diabetic retinopathy, and iatrogenic retinopathy. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
- ET”
-
18. A method for treating ocular disease or damage thereof in an animal, comprising administering to the animal, a composition containing an effective amount of an endothelin-converting-enzyme (“
- ECE”
) inhibitor in a pharmaceutically acceptable vehicle, wherein the ocular disease or damage is selected from the group consisting of ischemic retinopathies or optic neuropathies, commotio retinae, glaucoma, macular degeneration, retinitis pigmentosa, retinal detachment, retinal tears or holes, diabetic retinopathy, and iatrogenic retinopathy. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
- ECE”
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32. A method of treating an ocular disease in an animal, comprising:
- administering to the animal an effective amount of a mixture comprising a plurality of compounds, wherein the plurality of compounds comprise one or more endothelin-(“
ET”
) antagonists and one or more endothelin-converting-enzyme (“
ECE”
) inhibitors.
- administering to the animal an effective amount of a mixture comprising a plurality of compounds, wherein the plurality of compounds comprise one or more endothelin-(“
Specification