Physiologically compatible cardiac assist device and method

• US 20030176760A1
• Filed: 02/10/2003
• Published: 09/18/2003
• Est. Priority Date: 02/11/2002
• Status: Abandoned Application

• Current Assignee: National University of Singapore
• Original Assignee: National University of Singapore
• Inventors: Lim, Hou-Sen, El Oakley, Reida Menshawe
• Application Number:
  US10/365,706
• Publication Number:
  US 20030176760A1
• Time in Patent Office: Days
• US Class Current: 600/16
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3303 Using a biosensor
• CPC Class Codes: A61M 60/139 inside the aorta, e.g. intra-aortic balloon pumps
• CPC Class Codes: A61M 60/148 in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
• CPC Class Codes: A61M 60/178 drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
• CPC Class Codes: A61M 60/274 the inlet and outlet being the same, e.g. para-aortic counter-pulsation blood pumps
• CPC Class Codes: A61M 60/295 Balloon pumps for circulatory assistance
• CPC Class Codes: A61M 60/497 for balloon pumps for circulatory assistance
• CPC Class Codes: A61M 60/515 Regulation using real-time patient data
• CPC Class Codes: A61M 60/569 synchronous with the native heart beat

Abstract

A physiologically compatible cardiac assist device, also known as a ventricular assist device, has a pump which draws blood through a first catheter inserted into either the right atrium, the left atrium or the left ventricle and infuses the blood via a second catheter into the aorta during diastole. Attached to the second catheter is a balloon which is also inflated during diastole. The synchronized volume infusion and balloon inflation in this counterpulsation mode reduces afterload and is thus more physiologically compatible.

Claims

1. A physiologically compatible cardiac assist device for cardiac assistance and use during coronary artery bypass surgery on a patient with or without cardiopulmonary bypass, said device comprising:

a first catheter for insertion into the left or the right atrium directly or via the great veins, or into the left ventricle of the patient;

a second catheter for insertion into the aorta via the femoral or brachial artery of the patient, said catheter also capable of carrying an intra-aortic balloon for diastolic counter-pulsation;

a pump for drawing blood through said first catheter and for delivering blood through said second catheter to the aorta, said pump capable of inflating a pneumatically driven intra-aortic balloon;

a control system for monitoring the performance of the patient'"'"'s heart and for controlling operation of said pump to deliver blood and drive the intra-aortic balloon through said second catheter during only the diastolic phase of the cardiac cycle.

2. A cardiac assist device as claimed in claim 1 wherein said control system includes an electrocardiogram having electrodes that can be positioned to monitor the performance of the patient'"'"'s heart to identify the cardiac cycle thereof and to determine the duration of the diastolic phase and the systolic phase thereof, said electrocardiogram being connected to deliver to said control system input signals representing the cardiac cycle of the patient'"'"'s heart, said control system being effective to control operation of said pump in response to said input signals to ensure that said pump is actuated only during the diastolic phase of each cardiac cycle, operation of said pump being terminated before the onset of the systolic phase of each cardiac cycle.

3. A cardiac assist device as claimed in claims 1 or 2 including means for adjusting the duration and timing of actuation of the pump during each diastolic phase to control the volume of blood delivered through said second catheter.

4. A cardiac assist device as claimed in any one of claims 1 to 3 wherein said first catheter is sized to be inserted through an incision in the patient'"'"'s venous system, said second catheter being sized for insertion through an incision in the patient'"'"'s femoral artery and to be advanced through the femoral artery to a location at the patient'"'"'s descending thoracic aorta.

5. A method of cardiac assistance to maintain blood circulation in the body of a patient during heart failure and coronary artery bypass surgery, said method comprising:

a) inserting a first catheter into the left atrium or the femoral or internal jugular vein of the patient;

b) inserting a second catheter into a femoral artery of the patient;

c) monitoring the performance of the patient'"'"'s heart to identify the cardiac cycle thereof; and

d) drawing blood from said patient through said first catheter and returning blood to said patient through said second catheter in synchrony with the cardiac cycle of the patient such that blood is returned to the patient through said second catheter only during the diastolic phase of the cardiac cycle, flow of blood through said second catheter being terminated before the onset of the systolic phase.

6. The method of claim 5 wherein said first catheter is inserted to draw blood from the left atrium, superior vena cava or inferior vena cava.

7. The method of claims 5 or 6 wherein the second catheter is positioned to deliver blood into the descending thoracic aorta of the patient'"'"'s blood circulatory system.

8. The method of any one of claims 5 to 7 wherein blood is delivered in a pressure pulse of duration and magnitude that is synchronized with the pumping action of the heart and that augments the diastolic pressure to increase coronary blood flow and mean arterial pressure.

9. The method of any one of claims 5 to 8 wherein blood is returned through the second catheter in a manner to replicate and augment the pumping action of the heart.

10. A method of cardiac assistance to maintain blood circulation in the body of a patient during heart failure and coronary artery bypass surgery, said method comprising:

a) inserting a first catheter into the patient'"'"'s venous system;

b) inserting into the patient'"'"'s arterial system a second catheter with an inflatable balloon attached near its distal end;

c) positioning the distal end of said second catheter such that the balloon is located in the patient'"'"'s descending thoracic aorta;

d) monitoring the patient'"'"'s heart with electrical sensors to determine the diastolic phase; and

e) pumping blood from said patient through said first catheter and infusing said blood into said patient through said second catheter and simultaneously inflating the balloon such that the infusion of blood and the inflation of the balloon are both in synchrony with the patient'"'"'s diastolic phase.

11. The method of claim 10 wherein said first catheter is inserted into the left atrium or the femoral or internal jugular vein.

12. The method of claims 10 or 11 wherein the inflation of said balloon and the simultaneous infusion of blood into the aorta are controlled and synchronized by a control system.

13. The method of claim 12 wherein the control system receives input signals from electrocardiograph leads placed on the patient'"'"'s body.