Antibiotic textile materials suitable for wound dressings and wound dressings incorporating the same

• US 20030176827A1
• Filed: 12/20/2002
• Published: 09/18/2003
• Est. Priority Date: 12/20/2001
• Status: Active Grant

• Current Assignee: Noble Fiber Technologies LLC
• Original Assignee: Nobel Fiber Technologies LLC
• Inventors: McNally, William Francis, Furey, Joel M., Chandra, Satish N.
• Granted Patent: US 7,385,101 B2
• Time in Patent Office: Days
• US Class Current: 602/48
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria

Abstract

A hydrophilic textile matrix having antibiotic activity is provided. The textile matrix is a non-woven material including a blend (i.e., mixture) of metallic silver-coated fibers and a non-metallic, water absorbent material. Wound dressings incorporating the textile matrices are provided.

Claims

1. A hydrophilic textile matrix having antibiotic activity, said matrix being a non-woven material comprising a blend of metallic silver-coated fibers and non-metallic, water-absorbent material.

2. The textile matrix of claim 1, wherein said non-metallic, water-absorbent material is in the form of fibers.

3. The textile matrix of claim 1, wherein said non-metallic, water-absorbent material is in the form of a hydrogel.

4. The textile matrix of claim 1, wherein said matrix has a water absorption of at least 10 grams per gram of matrix.

5. The textile matrix of claim 4, wherein said water absorption is at least about 14 grams per gram of matrix.

6. The textile matrix of claim 5, wherein said water absorption is at least about 16 grams per gram of matrix.

7. The textile matrix of claim 1, wherein said non-metallic, water-absorbent material is a polysaccharide material.

8. The textile matrix of claim 7, wherein said polysaccharide material is a hydrocolloid.

9. The textile matrix of claim 8, wherein said hydrocolloid is an alginate or derivative thereof.

10. The textile matrix of claim 9, wherein said alginate is calcium alginate or a derivative thereof.

11. The textile matrix of claim 1, wherein said metallic silver-coated fibers are 0.5 to 50 denier per filament.

12. The textile matrix of claim 11, wherein said metallic silver-coated fibers are 0.7 to 30 denier per filament.

13. The textile matrix of claim 12, wherein said metallic silver-coated fibers are 1 to 10 denier per filament.

14. The textile matrix of claim 1, wherein said blend comprises about 1 to about 80 percent by weight of said metallic silver-coated fibers and about 10 to about 80 percent by weight of non-metallic, water-absorbent fibers.

15. The textile matrix of claim 14, wherein said blend comprises about 20 to about 70 percent by weight of said metallic silver-coated fibers and about 20 to about 70 percent by weight of non-metallic, water-absorbent fibers.

16. The textile matrix of claim 15, wherein said blend comprises about 30 to about 60 percent by weight of said metallic silver-coated fibers and about 30 to about 60 percent by weight of non-metallic, water-absorbent fibers.

17. A wound dressing comprising a flexible backing material and a layer of a hydrophilic textile matrix having anti-microbial activity disposed on one side of said backing material, said matrix comprising a non-woven material including a blend of metallic silver-coated fibers and a non-metallic, water-absorbent material.

18. The wound dressing of claim 17, wherein said backing layer includes an adhesive layer disposed on the same side as said hydrophilic textile matrix but excluding said hydrophilic textile matrix.