Multi-channel bioresorbable nerve regeneration conduit and process for preparing the same

• US 20030176876A1
• Filed: 06/04/2002
• Published: 09/18/2003
• Est. Priority Date: 03/11/2002
• Status: Abandoned Application

• Current Assignee: Duke University, Industrial Technology Research Institute
• Original Assignee: Duke University
• Inventors: Hsieh, Yu-Lin, Yang, Jean-Dean, Liu, Mei-Jun, Shen, Hsin-Hsin, Chen, Jui-Hsiang, Tsai, Bin-Hong, Yang, Chiung-Lin
• Application Number:
  US10/161,914
• Publication Number:
  US 20030176876A1
• Time in Patent Office: Days
• US Class Current: 606/152
• CPC Class Codes: A61B 17/1128 of nerves
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61L 2430/32 for nerve reconstruction
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A multi-channel bioresorbable nerve regeneration conduit and a process for preparing the conduit. The multi-channel bioresorbable nerve regeneration conduit includes a hollow round tube of a porous bioresorbable polymer and a multi-channel filler in the round tube. The multi-channel filler is a porous bioresorbable polymer film with an uneven surface and is single layer, multiple layer, in a folded form, or wound into a spiral shape.

Claims

1. A multi-channel bioresorbable nerve regeneration conduit, comprising:

a hollow round tube of a porous bioresorbable polymer; and

a multi-channel filler in the round tube, which is a porous bioresorbable polymer film with an uneven surface.

2. The nerve regeneration conduit as claimed in claim 1, wherein the hollow round tube has a wall with a thickness of 0.05 to 1.5 mm.

3. The nerve regeneration conduit as claimed in claim 1, wherein the pore on the wall of the hollow round tube is interconnected.

4. The nerve regeneration conduit as claimed in claim 1, wherein the hollow round tube is a porous bioresorbable polymer and is polycaprolactone (PCL), polylactic acid (PLA), polyglycolic acid (PGA), poly-lactic-co-glycolic acid copolymer (PLGA copolymer), polycaprolactone-polylactic acid copolymer (PCL-PLA copolymer), polycaprolactone-polyglycolic acid (PCL-PGA copolymer), polycaprolactone-polyethylene glycol copolymer (PCL-PEG copolymer), or mixtures thereof.

5. The nerve regeneration conduit as claimed in claim 1, wherein the conduit has more than 10 channels.

6. The nerve regeneration conduit as claimed in claim 1, wherein the porous bioresorbable polymer film with an uneven surface includes a base and a plurality of protrusions protruding from the surface of the base, and wherein the base has a thickness of 0.05 mm to 1.0 mm.

7. The nerve regeneration conduit as claimed in claim 6, wherein in the porous bioresorbable polymer film with an uneven surface, the protrusion has a protruding depth of 0.05 mm to 1.0 mm.

8. The nerve regeneration conduit as claimed in claim 1, wherein the porous bioresorbable polymer film with an uneven surface is polycaprolactone (PCL), polylactic acid (PLA), polyglycolic acid (PGA), poly-lactic-co-glycolic acid copolymer (PLGA copolymer), polycaprolactone-polylactic acid copolymer (PCL-PLA copolymer), polycaprolactone-polyglycolic acid (PCL-PGA copolymer), polycaprolactone-polyethylene glycol copolymer (PCL-PEG copolymer), or mixtures thereof.

9. The nerve regeneration conduit as claimed in claim 1, wherein the porous bioresorbable polymer film with an uneven surface is single layer, multiple layer, in a folded form, or wound into a spiral shape.

10. The nerve regeneration conduit as claimed in claim 9, wherein the porous bioresorbable polymer film with an uneven surface is wound into a spiral shape.

11. A process for preparing a multi-channel bioresorbable nerve regeneraton conduit, comprising:

forming a multi-channel filler, which is a porous bioresorbable polymer film with an uneven surface;

forming a hollow round tube of a porous bioresorbable polymer; and

placing the multi-channel filler into the hollow round tube.

12. The process as claimed in claim 11, wherein porous bioresorbable polymer film with an uneven surface is formed by the following steps:

dissolving a bioresorbable polymer in an organic solvent to form a bioresorbable polymer solution;

making the bioresorbable polymer solution have a film shape with an uneven surface; and

contacting the film-shaped solution with a coagulant to form a porous bioresorbable film with an uneven surface.

13. The process as claimed in claim 12, wherein the step of forming the bioresorbable polymer solution further comprises dissolving a low molecular weight oligomer in the organic solvent, wherein the low molecular weight oligomer has a molecular weight of 200 to 4000.

14. The process as claimed in claim 13, wherein the low molecular weight oligomer is polycaprolactone triol (PCLTL), polycaprolactone diol (PCLDL), polycaprolactone (PCL), polylactic acid (PLA), polyethylene glycol (PEG), polypropylene glycol (PPG), polytetramethylene glycol (PTMG), or mixtures thereof.

15. The process as claimed in claim 11, wherein the hollow round tube of porous bioresorbable polymer is formed by the following steps:

dissolving a bioresorbable polymer in an organic solvent to form a bioresorbable polymer solution;

making the bioresorbable polymer solution have a hollow round tube shape; and

contacting the hollow round tube-shaped solution with a coagulant to form the hollow round tube of the porous bioresorbable polymer.

16. The process as claimed in claim 15, wherein the hollow round tube of porous bioresorbable polymer is formed by the following steps:

dissolving a bioresorbable polymer in an organic solvent to form a bioresorbable polymer solution;

coating the bioresorbable polymer solution onto a surface of a rod to make the solution have a round tube shape;

placing the rod coated with the bioresorbable polymer solution into a coagulant to form a round tube shaped-porous bioresorbable material on the surface of the rod; and

drawing out the round tube-shaped porous bioresorbable material from the surface of the rod to obtain the porous bioresorbable hollow round tube.

17. The process as claimed in claim 16, wherein the step of forming the bioresorbable polymer solution further comprising dissolving a low molecular weight oligomer in the organic solvent, wherein the low molecular weight oligomer has a molecular weight of 200 to 4000.

18. The process as claimed in claim 17, wherein the low molecular weight oligomer is polycaprolactone triol (PCLTL), polycaprolactone diol (PCLDL), polycaprolactone (PCL), polylactic acid (PLA), polyethylene glycol (PEG), polypropylene glycol (PPG), polytetramethylene glycol (PTMG), or mixtures thereof.

19. The process as claimed in claim 11, wherein the porous bioresorbable polymer film with an uneven surface is single layer, multiple layer, in a folded form, or wound into a spiral shape.

20. The process as claimed in claim 19, wherein the porous bioresorbable polymer film with an uneven surface is wound into a spiral shape.