Everted filter device
First Claim
1. A filter device for filtering a body vessel fluid in a patient'"'"'s body, the vessel having interior walls, the filter device comprising:
- a filter body having an open proximal end region and a closed, everted distal end region, the filter body being formed of a porous mesh, the mesh defining a filter body interior and exterior, wherein the everted distal end region has an exterior distal everted cavity;
a first elongate member having a distal region operably coupled to the filter body distal end region; and
means for changing the degree of eversion of the filter body by changing the distance between the filter body proximal and distal end regions.
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Accused Products
Abstract
Everting filter devices and methods for using the devices, including using the devices as intra-vascular filters to filter thrombus, emboli, and plaque fragments from blood vessels. The filter devices include a filter body nominally tubular in shape and having a large proximal opening. The filter body can extend from a proximal first end region distally over the non-everted exterior surface of the filter, further extending distally to a distal-most region, then converging inwardly and extending proximally toward the filter second end region, forming a distal everted cavity. The degree of eversion of the filter can be controlled by varying the distance between the filler first end region near the proximal opening and the closed second end region. Bringing the filter first and second end regions closer together can bring filter material previously on the non-everted filter exterior to occupy the distal-most region. The everting process can also bring filter material previously in the distal-most position further into the distal everted cavity. The filter devices can be used to remove filtrate from body vessels, with the filtrate eventually occluding the distal-most region. The filter can then be further everted, bringing fresh, unoccluded filter material into place to provide additional filter capacity. Some everting filters have the capability of switching between occluding and filtering modes of operation, thereby allowing a treating physician to postpone the decision to use filtering or occluding devices until well after insertion of the device into the patient'"'"'s body.
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Citations
73 Claims
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1. A filter device for filtering a body vessel fluid in a patient'"'"'s body, the vessel having interior walls, the filter device comprising:
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a filter body having an open proximal end region and a closed, everted distal end region, the filter body being formed of a porous mesh, the mesh defining a filter body interior and exterior, wherein the everted distal end region has an exterior distal everted cavity;
a first elongate member having a distal region operably coupled to the filter body distal end region; and
means for changing the degree of eversion of the filter body by changing the distance between the filter body proximal and distal end regions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An everted filter device comprising:
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an elongate member having a proximal portion and a distal portion, the distal portion having a proximal region a distal region, and an outer surface; and
a mesh filter body having an average pore size, the filter body having a first end region slidably secured to the elongate member distal portion proximal region, a filter body second end region opposite the first end region fixedly secured to the elongate member distal portion distal region, a filter body intermediate region disposed between the filter body first and second end regions, and at least one proximal opening having a size at least five times the average filter body pore size, wherein the filter body has an everted distal exterior cavity having a length, wherein the filter body distal cavity length can be varied by varying the distance between the filter body first and second end regions. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method for capturing a filtrate material from a fluid in a body vessel, the method comprising the steps of
providing a filter device including an elongate member having a proximal portion and a distal portion, the distal portion having a proximal region, and a distal region, the filter device further including a mesh filter body formed of a filter material having an average pore size, the filter body having a first end region slidably secured to the elongate member distal portion proximal region, a filter body second end region opposite the first end region fixedly secured to the elongate member distal portion distal region, a filter body intermediate region disposed between the filter body first and second end regions, the filter body extending distally from the proximal opening and everting over a distal-most region to converge radially inwardly and proximally to form an exterior distal everted cavity, and at least one proximal opening having a size at least five times the average filter body pore size; -
advancing the filter body to a vessel region to be filtered;
deploying the filter device in a first configuration where the filter body has a first collection region of filter material occupying the distal-most region; and
collecting the filtrate in the filter body first collection region. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35)
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36. An everted filter device comprising:
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a first shaft having a proximal portion and a distal portion, the distal portion having a distal region;
a second shaft having a proximal portion, a distal portion, the distal portion having a distal region and a proximal region; and
a filter body formed of a porous mesh material having an average pore size, a first end region secured to the first shaft distal portion distal region, the filter body having a second end region secured to the second shaft distal portion distal region, the filter body having at least one proximal opening having an opening size at least five times the filter body average pore size, wherein the filter body distal region is everted when unconstrained to form an exterior distal everted cavity. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. An everted filter device comprising:
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a shaft having a proximal portion, a distal portion, the distal portion having a distal region; and
a porous mesh filter body having a first end region, a second end region, and an intermediate region disposed between the first and second end regions, the body having a proximal opening having a cross sectional area at least about five times the average pore cross sectional area of the filter body, wherein the opening is disposed within a proximal mouth region;
wherein the shaft is coupled to the filter body second end region, and the shaft distal region is coupled to the filter body proximal mouth region with at least two elongate fastening members. - View Dependent Claims (47, 48, 49, 50, 51, 52)
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53. An everted occluding/perfusing device comprising:
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a first shaft having a proximal portion and a distal portion, the distal portion having a distal region;
a second shaft having a proximal portion, a distal portion, the distal portion having a distal region and a proximal region; and
a mesh body having an average pore size, a first end region secured to the first shaft distal portion distal region, the mesh body having a second end region secured to the distal shaft distal portion distal region, the mesh body having at least one proximal opening having an opening size at least five times the mesh body average pore size, the mesh body having an interior and a exterior, wherein the mesh body distal region is everted when unconstrained to form a distal-most region and converges inwardly and proximally to form an exterior distal everted cavity, wherein the mesh body has a perfusing portion and an occluding portion disposed over the mesh body such that changing the degree of eversion of the mesh body changes the device between the occluding and perfusing portions being disposed in the distal-most region of the mesh body. - View Dependent Claims (54, 55, 56, 57, 58, 59)
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60. A method for filtering filtrate material from a body vessel fluid, the method comprising the steps of:
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providing a filter device including a filter body having a proximal opening disposed within a proximal mouth region, a closed everted distal region having a exterior distal everted cavity and a distal-most region, wherein the filter body has a filtering portion and an occluding portion oriented so that the filter body can be manipulated between an occluding mode and a filtering mode by changing the degree of eversion of the filter body, the filter device further including an elongate first member having a proximal end region, a proximal region and a distal region, the elongate first member distal region being coupled to the filter body closed everted region;
advancing the filtering device filter body to the body vessel region to be filtered;
manipulating the filter body to a first configuration so that the distal-most region of the filter body is occupied by the filter body occluding portion to substantially occlude flow of the vessel fluid;
changing the degree of eversion of the filter body so that the distal-most region of the filtering device is occupied by the filter body filtering portion to capture the filtrate; and
filtering the body vessel fluid to collect filtrate in the filter body distal-most region. - View Dependent Claims (61, 62, 63)
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64. A method for delivery an agent to a body vessel interior region, the method comprising the steps of:
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providing an infusion device including a filter body having a proximal opening disposed within a proximal mouth region, a closed everted distal region having a distal exterior everted cavity and a distal-most region, wherein the filter body has a filtering portion and an occluding portion oriented so that the filter body can be manipulated between an occluding mode and a filtering mode by changing the degree of eversion of the filter body, the infusion device further including an elongate first member having a proximal region and a distal region, the elongate first member distal region being coupled to the filter body closed everted region, the infusion device further including an infusion lumen disposed along the first elongate member and in fluid communication with a distal port;
advancing the infusion device filter body to the body vessel region to be treated;
manipulating the infusion device to a first configuration where the filter body has a region of occluding material occupying the distal-most region to reduce flow through the vessel and wherein the filter body has a region of filtering material facing the vessel interior walls to allow agent flow through the filtering material vessel walls; and
infusing the agent through the infusion lumen into the filter body interior to allow the agent to contact the vessel walls through the porous material. - View Dependent Claims (65, 66)
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67. A filter device comprising:
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a first shaft having a proximal portion and a distal portion, the distal portion having a distal region;
a second shaft having a proximal portion and a distal portion, the distal portion having a distal region and a proximal region; and
a porous filter body having an average pore size, a first end region secured to the first shaft distal portion distal region, the filter body having a second end region secured to the second shaft distal portion distal region, the filter body having at least one proximal opening having an opening size at least five times the filter body average pore size, wherein the filter body distal region is everted when unconstrained to form an exterior distal everted cavity, wherein at least one of the first or second shafts has a lumen therethrough in fluid communication with an inflatable envelope disposed within the filter body, wherein the inflatable envelope has a distal waist region and a proximal waist region, wherein the balloon has an inflated configuration for substantially occluding the filter body interior and a second configuration substantially less occluding than the first occluding configuration.
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68. A method for occluding and filtering a vessel region, the method comprising the steps of:
providing a filter device including;
a first shaft having a proximal portion and a distal portion, the distal portion having a distal region;
a second shaft having a proximal portion, a distal portion, the distal portion having a distal region and a proximal region; and
a porous mesh filter body having an average pore size, a first end region secured to the first shaft distal portion distal region, the filter body having a second end region secured to the second shaft distal portion distal region, the filter body having at least one proximal opening having an opening size at least five times the filter body average pore size, wherein the filter body distal region is everted when unconstrained to form an exterior distal everted cavity, wherein at least one of the first or second shafts has a lumen therethrough in fluid communication with an inflatable envelope disposed within the filter body, wherein the inflatable envelope has a distal waist region and a proximal waist region, wherein the balloon has an inflated configuration for substantially occluding the filter body interior and a second configuration substantially less occluding than the first occluding configuration;
advancing the filter device to a region to be filtered;
inflating the balloon to substantially occlude the vessel; and
uninflating the balloon to allow greater body fluid passage around the balloon. - View Dependent Claims (69)
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70. A method for removing blockage material from a vessel, the method comprising the steps of:
providing a filter device including;
a first shaft having a proximal portion and a distal portion, the distal portion having a distal region, a second shaft having a proximal portion, a distal portion, the distal portion having a distal region and a proximal region, and a filter body having an average pore size, a first end region secured to the first shaft distal portion distal region, the filter body having a second end region secured to the second shaft distal portion distal region, the filter body having at least one proximal opening having an opening size at least five times the filter body average pore size, wherein the filter body distal region is everted when unconstrained to form an exterior distal everted cavity, and a proximal loop disposed near the filter body proximal mouth region;
deploying the filtering device distally of the blockage material in a configuration where the proximal loop is in a substantially open configuration; and
proximally retracting the proximal loop over the blockage material such that the blockage material is at least partially captured within the filter interior while elongating the porous mesh filter. - View Dependent Claims (71, 72, 73)
Specification