Cardiac rhythm management system and method using time between mitral valve closure and aortic ejection
First Claim
1. A system including:
- an accelerometer, configured to detect an acceleration signal in a subject;
a mitral valve closure (MVC) detector circuit, coupled to the accelerometer to receive the acceleration signal, and configured to detect an MVC indication using information from the acceleration signal;
an aortic ejection (AE) detector circuit, configured to detect an AE indication;
a timer, coupled to the MVC detector circuit and the AE detector circuit, the timer configured to measure a time interval between the MVC indication and the AE indication; and
a classification module, coupled to the timer to receive the measured time interval, and configured to classify the subject based on the measured time interval.
1 Assignment
0 Petitions
Accused Products
Abstract
This document discusses cardiac rhythm management systems and methods using the MVC-to-AE time between mitral valve closure (“MVC”) and aortic ejection (“AE”) of the same heart contraction, sometimes referred to as the isovolumic contraction time (“ICVT”). In one example, the MVC-to-AE time is used for predicting which patients will respond to cardiac resynchronization therapy (CRT), or other therapy. In another example, the MVC-to-AE time is used as a wellness indicator. In a further example, the MVC-to-AE time is used to select or control a therapy or therapy parameter. In one example, the MVC and AE are obtained using an accelerometer signal, however, plethysmography, tonometry, or other techniques may alternatively be used.
132 Citations
79 Claims
-
1. A system including:
-
an accelerometer, configured to detect an acceleration signal in a subject;
a mitral valve closure (MVC) detector circuit, coupled to the accelerometer to receive the acceleration signal, and configured to detect an MVC indication using information from the acceleration signal;
an aortic ejection (AE) detector circuit, configured to detect an AE indication;
a timer, coupled to the MVC detector circuit and the AE detector circuit, the timer configured to measure a time interval between the MVC indication and the AE indication; and
a classification module, coupled to the timer to receive the measured time interval, and configured to classify the subject based on the measured time interval. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
-
-
18. A method including:
-
detecting in a subject an accelerometer-based mitral valve closure (MVC) indication;
detecting an aortic ejection (AE) indication;
measuring a time interval between the MVC indication and the AE indication; and
classifying the subject based on the measured time interval. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
-
-
41. A system including:
-
an accelerometer, configured to detect an acceleration signal in a subject;
a mitral valve closure (MVC) detector circuit, coupled to the accelerometer to receive the acceleration signal, and configured to detect an MVC indication using information from the acceleration signal;
an aortic ejection (AE) detector circuit, configured to detect an AE indication;
a timer, coupled to the MVC detector circuit and the AE detector circuit, the timer configured to measure a time interval between the MVC indication and the AE indication; and
a wellness indicator module, coupled to the timer to receive the measured time interval, and configured to compute a wellness indication of the subject based on the measured time interval. - View Dependent Claims (42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
-
-
57. A method including:
-
detecting in a subject an accelerometer-based mitral valve closure (MVC) indication;
detecting an aortic ejection (AE) indication;
measuring a time interval between the MVC indication and the AE indication; and
computing a wellness indication of the subject based on the measured time interval. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79)
-
Specification