Pathlength-independent methods for optically determining material composition
First Claim
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1. A method for using spectroscopy to determine an analyte concentration in a sample, the method comprising:
- producing an absorbance spectrum of the sample;
shifting the absorbance spectrum to zero in a wavelength region; and
subtracting a water or other substance contribution from the absorbance spectrum.
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Abstract
A method uses spectroscopy to determine an analyte concentration in a sample. The method includes producing an absorbance spectrum of the sample. The method further includes shifting the absorbance spectrum to zero in a wavelength region. The method further includes subtracting a water or other substance contribution from the absorbance spectrum.
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Citations
18 Claims
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1. A method for using spectroscopy to determine an analyte concentration in a sample, the method comprising:
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producing an absorbance spectrum of the sample;
shifting the absorbance spectrum to zero in a wavelength region; and
subtracting a water or other substance contribution from the absorbance spectrum. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of providing pathlength insensitive measurements of blood constituents in a sample using infrared (IR) spectroscopy, the method comprising:
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providing an absorbance spectrum of the sample;
shifting the absorbance spectrum to zero at an isosbestic wavelength, wherein water and a protein within the sample have approximately equivalent absorptions at the isosbestic wavelength.
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Specification