Antibacterial agents
First Claim
1. A panel of bacteriophages comprising a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, aid a second vir mutant capable of infecting and lysing a second strain of bacteria.
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Accused Products
Abstract
A panel of bacteriophages having a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, and a second vir mutant capable of infecting and lysing a second strain of bacteria. A pharmaceutical composition including a panel of bacteriophages disclosed above. A method of identifying a bacteriophage suitable for killing a bacterium by obtaining a sample of the bacterium from a patient or site infected with the bacterium, identifying one or more phage sensitivity characteristics of the bacterium, comparing the characteristics from the identification step with the known host range of each library of bacteriophages, the library of bateriophages including a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, and a second vir mutant capable of infecting and lysing a second strain of bacteria, and identifying one or more bacteriophages from the panel suitable for killing the bacterium.
24 Citations
28 Claims
- 1. A panel of bacteriophages comprising a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, aid a second vir mutant capable of infecting and lysing a second strain of bacteria.
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14. A method of identifying a bacteriophage suitable for killing a bacterium, comprising the steps of:
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(i) obtaining a sample of said bacterium from patient or place infected with said bacterium;
(ii) identifying one or more phage sensitivity characteristics of said bacterium;
(iii) comparing the characteristics from step (ii) with the known host range of each bacteriophage of a library of bacteriophages said library of bacteriophages comprising a first vir mutant bacteriophage capable of infecting and lysing a first strain of bacteria, and a second vir mutant capable of infecting and lysing a second strain of bacteria; and
(iv) identifying one or more bacteriophages from the panel suitable for killing said bacterium. - View Dependent Claims (15, 18)
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16. A method of identifying the presence of one or more prophages in a bacterium comprising a pair of primers capable of hybridising under high stringency conditions to a prophage nucleotide sequence, and carrying our PCR to identify the presence of said prophage.
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24. A method of identifying a bacteriophage for treating an animal or plant infected with a bacterial pathogen, comprising:
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(i) isolating said bacterial pathogen;
(ii) isolating a lysogenic bacteriophage from the bacterium; and
(iii) mutating said lysogenic bacteriophage to produce a vir mutant of the lysogenic bacteriophage. - View Dependent Claims (25, 26)
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28. A primer pair for identifying the presence of an integrase gene of a bacteriophage by PCR, comprising nucleotide sequence selected from:
Specification