Methods for producing glass substrates for use in biopolymeric microarrays
First Claim
1. A method for producing a glass substrate, said method comprising:
- (a) providing a glass sheet suitable for scribing;
(b) scribing at least one scribe line in said glass sheet with a laser, whereby the power of said laser is reduced at the beginning and ending of each of said at least one scribe line relative to the laser working power of the laser used to scribe the remaining portions of said at least one scribe line; and
(c) singulating said scribed glass at said at least one scribe line to produce at least one laser scribed glass substrate, whereby each of said laser scribed glass substrates comprises straight and smooth ends substantially free of edge protrusions.
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Abstract
Methods for producing glass substrates having scribed edges with straight and smooth ends substantially free of edge protrusions, and microarray glass substrates produced thereby, are provided. In certain embodiments, at least one scribe line is scribed in glass using reduced laser power at the beginning and end of each scribe line relative to the laser power used to scribe the remaining portions of each respective scribe line. In other embodiments, a heat absorbing laser element is positioned adjacent the beginning and end of each scribe line. In all embodiments, the scribed glass is singulated to produce a plurality of scribed glass pieces, each having straight and smooth ends substantially free of edge protrusions. The scribed glass can be used as substrates for biopolymeric microarrays. Also provided are biopolymeric microarrays produced from the subject methods and kits which include the subject microarrays, as well as methods for using the same.
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Citations
38 Claims
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1. A method for producing a glass substrate, said method comprising:
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(a) providing a glass sheet suitable for scribing;
(b) scribing at least one scribe line in said glass sheet with a laser, whereby the power of said laser is reduced at the beginning and ending of each of said at least one scribe line relative to the laser working power of the laser used to scribe the remaining portions of said at least one scribe line; and
(c) singulating said scribed glass at said at least one scribe line to produce at least one laser scribed glass substrate, whereby each of said laser scribed glass substrates comprises straight and smooth ends substantially free of edge protrusions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 22, 23, 24, 25, 26, 27, 28, 29, 30, 35, 36)
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11. A method for producing a glass substrate, said method comprising:
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(a) providing a glass sheet suitable for laser scribing, (b) positioning a laser entrance element adjacent the beginning of at least one scribe line and a laser exit element positioned adjacent the ending of at least one scribe line, (c) scribing at least one laser scribe line in said glass sheet with a laser, whereby heat generated from said laser is absorbed by said laser entrance element and said laser exit element, and (d) singulating said scribed glass at the formed said at least one laser scribe line to produce at least one laser scribed glass substrate, whereby each of said laser scribed glass substrates comprises straight and smooth ends substantially free of edge protrusions. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 37, 38)
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- 31. A method comprising inserting a glass substrate carrying an array of probes on a surface into a holder, wherein said glass substrate has straight and smooth ends substantially free of edge protrusions.
Specification