Diagnosis and classification of disease and disability using low frequency magnetic field designed pulses (Cnps)

• US 20030181791A1
• Filed: 12/16/2002
• Published: 09/25/2003
• Est. Priority Date: 06/08/2000
• Status: Active Grant

• Current Assignee: Fralex Therapeutics, Inc.
• Original Assignee: Fralex Therapeutics, Inc.
• Inventors: White, Kevin, Thomas, Alex, Prato, Frank
• Granted Patent: US 7,280,861 B2
• Time in Patent Office: Days
• US Class Current: 600/300
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/4023 Evaluating sense of balance
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems

Abstract

The invention is directed to the use of magnetic field designed pulses for the diagnoses and classification of severity of disease states and disability in humans and animals.

Claims

1. The use of a Cnps for the diagnosis of a disease condition in a subject.

2. The use of claim 1, wherein said use diagnoses the severity of said disease condition.

3. A method for the diagnosis of disease conditions in a subject, the method comprising:

exposing a subject to a Cnps for a time effective to produce a physiological response;

monitoring a selected physiological function;

evaluating a change in the selected physiological function;

assessing the change in the selected physiological function; and

classifying the subject into a disease category based on the assessment of the change in the selected physiological function.

4. The method of claim 3, wherein said Cnps is targeted to a specific tissue.

5. The method of claim 4, wherein said Cnps is selected to affect a specific physiological function.

6. The method of claim 5, wherein said physiological function is selected from the group consisting of a motor function and a cognitive function.

7. The method of claim 6, wherein said method is able to diagnose central nervous disorders.

8. The method of claim 7, wherein said method is able to diagnose a disease condition selected from the group consisting of Parkinson'"'"'s disease, Huntington'"'"'s chorea and Multiple Sclerosis.

9. The method of claim 6, wherein said method is able to diagnose peripheral disorders.

10. The method of claim 9, wherein said peripheral disorders are selected from the group consisting of rheumatoid arthritis, fibromyalgia, muscular dystrophy and general pain.

11. The method of claim 3, wherein said method is used to diagnose actual pain and fatigue compared to feigned pain and fatigue.

12. The method of claim 3, wherein said method is used to diagnose disability.

13. The method of claim 3, wherein a change in the selected physiological function is assessed objectively and/or subjectively.

14. A method for the diagnosis and assessment of disease conditions in a subject, the method comprising:

exposing a subject simultaneously to a selected Cnps and a first prescribed light intensity and frequency distribution while monitoring a selected physiological function;

exposing said subject a second time simultaneously to said selected Cnps and a different light intensity of the same or different frequency distribution as said first prescribed light intensity while monitoring a selected physiological function; and

evaluating any change in the selected physiological function;

assessing said change in the selected physiological function; and

classifying said subject into a disease category based on the assessment of the change in the selected physiological function.

18. The method of any one of claims 14, 15, 16 or 17, wherein said Cnps is targeted to a specific tissue.

19. The method of any one of claims 14, 15, 16 or 17, wherein said Cnps is selected to affect a specific physiological function.

20. The method of claim 19, wherein said physiological function is selected from the group consisting of a motor function and a cognitive function.

21. The method of claim 20, wherein said method is able to diagnose central nervous disorders.

22. The method of claim 21, wherein said method is able to diagnose a disease condition selected from the group consisting of Parknson'"'"'s disease, Huntington'"'"'s chorea and Multiple Sclerosis.

23. The method of claim 20, wherein said method is able to diagnose peripheral disorders.

24. The method of claim 23, wherein said peripheral disorders are selected from the group consisting of rheumatoid arthritis, fibromyalgia, muscular dystrophy and general pain.

25. The method of any one of claims 14, 15, 16 or 17, wherein said method is used to diagnose actual pain and fatigue compared to feigned pain and fatigue.

26. The method of any one of claims 14, 15, 16 or 17, wherein said method is used to diagnose disability.

27. The method of any one of claims 14, 15, 16 or 17, wherein a change in the selected physiological function is assessed objectively and/or subjectively.

15. A method for the diagnosis and assessment of disease conditions in a subject, the method comprising;

exposing a subject to a first selected Cnps while monitoring a selected physiological function;

exposing said subject a second time to a second selected Cnps while monitoring a selected physiological function;

evaluating any change in the selected physiological function;

assessing said change in the selected physiological function; and

classifying said subject into a disease category based on the assessment of the change in the selected physiological function.

16. A method for the diagnosis of disease conditions in a subject, the method comprising;

evaluating a selected physiological function in a subject;

exposing said subject to a selected Cnps;

evaluating any change in the selected physiological function;

assessing said change in the selected physiological function; and

classifying said subject into a disease category based on the assessment of the change in the selected physiological function.

17. A method for the diagnosis of disease conditions in a subject, the method comprising;

exposing a subject simultaneously to two or more selected Cnps while monitoring at least one selected physiological function;

evaluating any change in at least one selected physiological function;

assessing said change in at least one selected physiological function; and

classifying said subject into a disease category based on the assessment of the change in the at least one selected physiological function.

28. The use of a Cnps for the assessment of feigned pain and/or fatigue in a subject.

29. A method for measuring pain, fatigue and/or disability in a subject, the method comprising:

exposing a subject to a selected Cnps while simultaneously monitoring a selected physiological function;

comparing the physiological function with that of a suitable control;

classifying the subject as experiencing pain, fatigue and/or a disability of feigning pain, fatigue and/or a disability.

30. A system for the diagnosis of disease conditions in a subject, the system comprising;

a coil array that produces a uniform magnetic field that perturbs a physiological function in a subject that is quantitatively or qualitatively assessed to generate a data set;

a data set representing a control;

wherein the two data sets are comparatively analyzed to classify the subject in a disease category.

31. A method for the diagnosis and assessment of disease conditions in a subject, the method comprising;

comparing a data set representing the perturbation of a physiological function in a subject with a data set representing a control;

classifying the subject in a disease category.