Capillary flow for a heterogenous assay in a micro-channel environment
First Claim
1. An apparatus comprising:
- a first channel, wherein a fluid flows through said first channel, wherein said first channel comprises;
an upstream region;
a tagging region downstream of said upstream region, wherein an analyte is tagged when said fluid flows through said tagging region;
a capture region downstream of said tagging region, wherein at least one tagged analyte is captured when said fluid flows through said capture region;
a second channel communicating said upstream region of said first channel with said first channel intermediate said tagging region and capture regions, wherein a portion of said fluid flows through said second channel and subsequently flows into said capture region of said first channel; and
wherein said fluid flowing through said tagging region flows into said capture region before said portion of said fluid flowing through said second channel flows into said capture region of said first channel.
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Abstract
Apparatus and methods consistent with certain principles related to the present invention include a first channel, where a fluid flows through the first channel, where the first channel comprises an upstream region, a tagging region downstream of the upstream region, where at least one analyte is tagged when the fluid flows through the tagging region, a capture region downstream of the tagging region, where at least one tagged analyte is captured when the fluid flows through the capture region. A second channel communicating the upstream region of the first channel with the first channel intermediate the tagging region and capture regions, where a portion of the fluid flows through the second channel and subsequently flows into the capture region of the first channel, and where the fluid flowing through the tagging region flows into the capture region before the portion of the fluid flowing through the second channel flows into the capture region of the first channel.
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Citations
20 Claims
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1. An apparatus comprising:
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a first channel, wherein a fluid flows through said first channel, wherein said first channel comprises;
an upstream region;
a tagging region downstream of said upstream region, wherein an analyte is tagged when said fluid flows through said tagging region;
a capture region downstream of said tagging region, wherein at least one tagged analyte is captured when said fluid flows through said capture region;
a second channel communicating said upstream region of said first channel with said first channel intermediate said tagging region and capture regions, wherein a portion of said fluid flows through said second channel and subsequently flows into said capture region of said first channel; and
wherein said fluid flowing through said tagging region flows into said capture region before said portion of said fluid flowing through said second channel flows into said capture region of said first channel. - View Dependent Claims (2, 3, 4, 5)
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6. An apparatus comprising:
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a first channel, wherein a first fluid flows through said first channel, wherein said first channel comprises;
an upstream region;
a tagging region downstream of said upstream region, wherein one analyte is tagged when said first fluid flows through said tagging region;
a capture region downstream of said tagging region, wherein at least one tagged analyte is captured when said first fluid flows through said capture region;
a second channel in fluid communication with said first channel intermediate said tagging region and said capture region;
a trigger channel communicating said first channel, wherein said first fluid flows through said trigger channel toward said second channel, causing a second fluid to flow through said second channel and subsequently flow into said capture region of said first channel;
wherein said first fluid flowing through said tagging region flows into said capture region before said second fluid flows through said second channel into said capture region of said first channel. - View Dependent Claims (7, 8, 9, 10)
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11. An apparatus comprising:
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a first channel wherein a first fluid flows through said first channel, wherein said first channel comprises;
an upstream region;
a tagging region downstream of said upstream region, wherein at least one analyte is tagged when said first fluid flows through said tagging region;
a capture region downstream of said tagging region, wherein at least one tagged analyte is captured when said first fluid flows through said capture region;
a second channel, communicating with said first channel intermediate said tagging region and said capture region, wherein a second fluid flows through said second channel and subsequently flows into said capture region of said first channel;
wherein said first fluid flowing through said tagging region flows into said capture region before said second fluid flows through said second channel into said capture region of said first channel. - View Dependent Claims (12, 13, 14, 15)
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16. An apparatus comprising:
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a first channel wherein a first fluid flows through said first channel, wherein said first channel comprises;
an upstream region;
a tagging region downstream of said upstream region, wherein at least one analyte is tagged when said first fluid flows through said tagging region;
a capture region downstream of said tagging region, wherein at least one tagged analyte is captured when said first fluid flows through said capture region;
a second channel, communicating with said first channel intermediate said tagging region and said capture region, wherein a second fluid flows through said second channel and flows into said capture region of said first channel;
wherein said first fluid flowing through said tagging region flows into said capture region after said second fluid flows through said second channel into said capture region of said first channel. - View Dependent Claims (17, 18, 19, 20)
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Specification