Paramagnetic particles that provide improved relaxivity
First Claim
1. A contrast agent for magnetic resonance imaging (MRI), which agent comprises particles, wherein said particles are coupled to a chelator containing a paramagnetic ion which ion is positioned offset from the surface of the particles, so as to provide said ion substantial access to hydrogen nuclei in a surrounding liquid, whereby the relaxivity of said nuclei is enhanced.
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Accused Products
Abstract
An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent.
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Citations
30 Claims
- 1. A contrast agent for magnetic resonance imaging (MRI), which agent comprises particles, wherein said particles are coupled to a chelator containing a paramagnetic ion which ion is positioned offset from the surface of the particles, so as to provide said ion substantial access to hydrogen nuclei in a surrounding liquid, whereby the relaxivity of said nuclei is enhanced.
Specification