Interleukin 10
First Claim
1. A conjugate exhibiting IL-10 activity comprising i) a polypeptide which comprises an amino acid sequence that differs from the amino acid sequence shown in SEQ ID NO 2 in at least one amino acid residue selected from an introduced or removed amino acid residue comprising an attachment group for the non-polypeptide moiety of ii), and ii) a non-polypeptide moiety.
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Accused Products
Abstract
Conjugates exhibiting IL-10 activity comprising (i) a polypeptide which comprises an amino acid sequence that differs from that of human IL-10 in at least one amino acid residue selected from an introduced or removed amino acid residue comprising an attachment group for the non-polypeptide moiety of (ii), and (ii) a non-polypeptide moiety. The conjugates have increased half-life as compared to hIL-10 and may be used for treatment of, e.g., inflammatory diseases.
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Citations
29 Claims
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1. A conjugate exhibiting IL-10 activity comprising
i) a polypeptide which comprises an amino acid sequence that differs from the amino acid sequence shown in SEQ ID NO 2 in at least one amino acid residue selected from an introduced or removed amino acid residue comprising an attachment group for the non-polypeptide moiety of ii), and ii) a non-polypeptide moiety.
Specification