Device for chemical and biochemical reactions using photo-generated reagents
First Claim
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1. A device for selectively converting photogenerated reagent precursors to photogenerated reagents comprising:
- a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites; and
b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein said optical system selectively irradiates a plurality of reaction sites.
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Abstract
This invention provides method and apparatus for performing chemical and biochemical reactions in solution using in situ generated photo-products as reagent or co-reagent. Specifically, the method and apparatus of the present invention have applications in parallel synthesis of molecular sequence arrays on solid surfaces.
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Citations
27 Claims
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1. A device for selectively converting photogenerated reagent precursors to photogenerated reagents comprising:
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a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites; and
b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein said optical system selectively irradiates a plurality of reaction sites. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A device for selectively converting photogenerated reagent precursors to photogenerated reagents for effecting a chemical reaction comprising:
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a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites, wherein said reaction sites comprise one or more reagents and contain a solution of at least one photogenerated reagent precursor; and
b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, which optical system selectively irradiates a plurality of reaction sites thereby converting the photogenerated reagent precursors to photogenerated reagents thereby effecting a chemical reaction. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A device for selectively converting photogenerated reagent precursors to photogenerated reagents for effecting deprotection of one or more initiating moieties comprising:
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a) a substrate comprising at least one solid surface containing a plurality of spatially separated reaction sites, wherein said reaction sites comprise one or more initiating moieties and contain a solution of at least one photogenerated reagent precursor; and
b) an optical system operably linked to the substrate comprising a light source and a computer-controlled spatial optical modulator to form an irradiation pattern, wherein said optical system selectively irradiates a plurality of reaction sites whereby said initiating moieties are deprotected by conversion of said photogenerated reagent precursors to photogenerated reagents. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
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Specification