Method of making a compound precursor by coating

• US 20030190418A1
• Filed: 08/07/2002
• Published: 10/09/2003
• Est. Priority Date: 04/03/2002
• Status: Active Grant

• Current Assignee: Biotech Industries Incorporated
• Original Assignee: Biotech Industries Incorporated
• Inventors: Tseng, How
• Granted Patent: US 6,723,380 B2
• Time in Patent Office: Days
• US Class Current: 427/222
• CPC Class Codes: A61L 27/32 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/425 of phosphorus containing material, e.g. apatite
• CPC Class Codes: A61L 31/082 Inorganic materials
• CPC Class Codes: A61L 31/127 containing fillers of phosphorus-containing inorganic materials
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention is to provide a method of making a polymer compound material by coating an inorganic material on the surface of a polymer. The method provided by the present invention comprises the step of spraying a high volatile solvent to a chipped polymeric matrix to slightly dissolve the surface of the matrix, and the step of adding inorganic material powders to let the powders be coated on the surface of the matrix layer by layer so as to form the polymer compound material.

Claims

1. A method of making a compound precursor adapted to be further used in an injection-molding processing, an extrusion processing or the like, the method comprising the steps of:

(a) selecting a biodegradable and bioabsorbable polymer material and then forming the selected polymer material into a chipped matrix;

(b) using a solvent to dissolve the surface of said chipped matrix slightly; and

(c) coating the surface-dissolved chipped matrix with a reinforced filler, thereby forming a heterogeneous precursor.

2. The method as claimed in claim 1, wherein said reinforced filler is a powdered inorganic material.

3. The method as claimed in claim 1, wherein the solvent used in step (b) contains a predetermined amount of said chipped matrix.

4. The method as claimed in claim 3, wherein the concentration of said chipped matrix in said solvent is within about 1%˜

10%.

5. The method as claimed in claim 1, wherein the solvent used in step (b) contains a predetermined amount of said reinforced filler.

6. The method as claimed in claim 1, wherein the reinforced filler used in step (c) is mixed with a solvent before application.

7. The method as claimed in claim 3, wherein the reinforced filler used in step (c) is mixed with a solvent before application.

8. The method as claimed in one of the claims from 1 through 7, further comprising a drying step of drying the heterogeneous precursor thus obtained.

9. The method as claimed in claim 8, wherein said drying step is to dry the heterogeneous precursor with hot air.

12. The method as claimed in claim 1, wherein said polymer material is selected from the group consisting of polylactide, polyglycolid, polyglycolide/polylactide copolymer, glycolide/trimethylene carbonate copolymer, poly-β

-hydroxybutyric acid, poly-β

-hydroxypropionic acid, poly-p-dioxanone, poly(N-acetyl-β

1,4-glucosamine), and polycaprolactone.

13. The method as claimed in claim 1, wherein said reinforced filler is selected from the group consisting of hydroxyapatite, aluminum oxide, calcium phosphate, dicalcium phosphate, apatite, mixture of magnesium calcium phosphate and tricalcium phosphate, and mixture of hydroxyapatite and tricalcium phosphate.

14. The method as claimed in claim 1, wherein said solvent is selected from dichloromethane, chloroform, tetrahydrofuran or naphethalene.

15. The method as claimed in claim 1, wherein the steps (a), (b), and (c) are performed in an enclosed chamber.

16. The method as claimed in claim 15, wherein said enclosed chamber is provided with a rotary member adapted for rotating said chipped matrix;

said solvent and said reinforced filler are supplied by spraying during step (b) and step (c) respectively.

17. The method as claimed in claim 16, wherein a hot air source is provided below said enclosed chamber and adapted for providing hot air into said enclosed chamber to dry the precursor thus obtained.

18. The method as claimed in claim 16, wherein said rotary member is a hollow rounded rotary device having a plurality of through holes through the periphery thereof and a baffle disposed on the inside and adapted for causing said chipped matrix to turn in different directions upon rotary motion of said rotary member;

a first spray gun is provided and adapted for applying said solvent to said chipped matrix;

a second spray gun is provided and adapted for applying said reinforced filler to said surface-dissolved chipped matrix.

10. A method of making a compound precursor comprising the steps of:

(a) selecting a biodegradable and bioabsorbable polymer material and then forming the selected polymer material into a chipped matrix; and

(b) mixing a reinforced filler in a solvent to form a mixture, and then spraying said mixture onto said chipped matrix to dissolve the surface of said chipped matrix and to let said reinforced filler be coated on the surface of said chipped matrix, thereby forming the precursor.

11. The method as claimed in claim 10, further comprising a drying step of drying the precursor thus obtained.