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Methods for generating databases and databases for identifying polymorphic genetic markers

  • US 20030190644A1
  • Filed: 10/15/2002
  • Published: 10/09/2003
  • Est. Priority Date: 10/13/1999
  • Status: Abandoned Application
First Claim
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1. A high throughput method of determining frequencies of genetic variations, comprising:

  • selecting a healthy target population and a genetic variation to be assessed;

    pooling a plurality of samples of biopolymers obtained from members of the population;

    determining or detecting the biopolymer that comprises the variation by mass spectrometry;

    obtaining a mass spectrum or a digital representation thereof; and

    determining the frequency of the variation in the population.

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