Filler for separation of enantiomeric isomers in simulated moving bed chromatography
First Claim
1. A filler for enantiomeric isomer separation for simulated moving bed chromatography having a porous carrier carrying a polysaccharide derivative thereon, wherein the filler has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below shown formula (I), obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method:
-
TS coefficient=[Vc−
[t(TS)−
t(blank)]×
FR]/[t(TS)−
t(blank)]×
FR
(I) (wherein abbreviations mean the following;
Vc (cm3) ;
a column volume;
FR (ml/min.);
a flow velocity;
t(TS) (min.);
an elution time for tetrakis(trimethylsilyl)silane (=TS); and
t(blank) (min.) ;
an elution time for TS in the state where the column is not connected).
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides a filler having a high productivity suitable for preparative separation by simulated moving bed chromatography. That is, there is provided a filler for enantiomeric isomer separation by simulated moving bed chromatography, which has a porous carrier carrying a polysaccharide derivative thereon and has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below-shown formula (I), abd obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method:
TS coefficient=[Vc−[t(TS)−t(blank)]×FR]/[t(TS)−t(blank)]×FR (I)
(wherein abbreviations mean the following:
Vc (cm3): a column volume;
FR (ml/min.): a flow velocity;
t(TS) (min.): an elution time for tetrakis(trimethylsilyl)silane (=TS); and
t(blank) (min.): an elution time for TS in the state where the column is not connected).
18 Citations
13 Claims
-
1. A filler for enantiomeric isomer separation for simulated moving bed chromatography having a porous carrier carrying a polysaccharide derivative thereon, wherein the filler has a TS coefficient in a range of 0.55 to 1.20, the TS coefficient being defined by the below shown formula (I), obtained by using an enantiomeric isomer separation column for simulated moving bed chromatography in which the filler is filled in a column tube by a slurry filling method:
-
TS coefficient=[Vc−
[t(TS)−
t(blank)]×
FR]/[t(TS)−
t(blank)]×
FR
(I)(wherein abbreviations mean the following;
Vc (cm3) ;
a column volume;
FR (ml/min.);
a flow velocity;
t(TS) (min.);
an elution time for tetrakis(trimethylsilyl)silane (=TS); and
t(blank) (min.) ;
an elution time for TS in the state where the column is not connected).- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
Specification