Human genome-derived single exon nucleic acid probes useful for gene expression analysis two
First Claim
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1. A nucleic acid probe for measuring human gene expression, comprising:
- a nucleotide sequence as set forth in any one of SEQ ID NOs;
13,701-27,400, the complement thereof, or a fragment of said SEQ ID NO;
or said complement, wherein said probe is a single exon probe that hybridizes under high stringency conditions to a nucleic acid molecule expressed in human cells or tissues.
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Abstract
Methods and apparatus for predicting, confirming and displaying functional regions from genomic sequence data are used to identify 13,700 unique human genome-derived single exon probes useful for gene expression analysis, particularly gene expression analysis by microarray. Also presented are genome-derived single exon microarrays that include such probes, peptides encoded by the exons, and antibodies thereto.
176 Citations
53 Claims
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1. A nucleic acid probe for measuring human gene expression, comprising:
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a nucleotide sequence as set forth in any one of SEQ ID NOs;
13,701-27,400, the complement thereof, or a fragment of said SEQ ID NO;
or said complement,wherein said probe is a single exon probe that hybridizes under high stringency conditions to a nucleic acid molecule expressed in human cells or tissues. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 48, 49, 50, 51, 52, 53)
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28. A nucleic acid probe for measuring human gene expression, comprising:
a nucleotide sequence that encodes, or the complement of which encodes, at least 8 amino acids of any one of SEQ ID NOs;
27,401-34,288,wherein said probe is a single exon probe that hybridizes under high stringency conditions to a nucleic acid molecule expressed in human cells or tissues.
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45. An ORF-encoded peptide, comprising:
- at least 8 contiguous amino acids of any one of SEQ ID NOs;
27,401-34,288 or at least 8 contiguous amino acids of any one of SEQ ID NOs;
27,401-34,288 with conservative amino acid substitutions. - View Dependent Claims (46, 47)
- at least 8 contiguous amino acids of any one of SEQ ID NOs;
Specification