Use of ectoin or ectoin derivatives for stabilizing p53

• US 20030199446A1
• Filed: 03/04/2003
• Published: 10/23/2003
• Est. Priority Date: 09/04/2000
• Status: Abandoned Application

• Current Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Original Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Inventors: Marchio, Francois, Bunger, Joachim
• Application Number:
  US10/363,469
• Publication Number:
  US 20030199446A1
• Time in Patent Office: Days
• US Class Current: 514/5.5
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 8/4953 containing pyrimidine ring derivatives, e.g. minoxidil
• CPC Class Codes: A61P 17/16 Emollients or protectives, e.g. against radiation
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61Q 1/04 for lips
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/001 Preparations for care of the lips
• CPC Class Codes: A61Q 19/004 Aftersun preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: A61Q 5/00 Preparations for care of the hair
• CPC Class Codes: A61Q 5/02 Preparations for cleaning the hair
• CPC Class Codes: A61Q 5/06 Preparations for styling the hair, e.g. by temporary shaping or colouring

Abstract

This invention relates to the use of at least one compound, selected from a compound of the formula 1a, 1b,

a physiologically compatible salt of it and a stereoisomeric form of it, whereby the following signify

R¹ H or alkyl,

R² H, COOH, COO-alkyl or CO—NH—R⁵,

R³ and R⁴ each mutually independent H or OH,

n 1, 2 or 3,

R⁵ H, alkyl, an amino acid residue, a dipeptide residue or tripeptide residue, and

alkyl an alkyl residue with 1 to 4 carbon atoms,

for the stabilisation of p53.

According to the invention, these compounds are normally used in the form of a topical composition.

Claims

1. Use of at least one compound, selected from a compound with the formula 1a, 1b,

2. Use according to claim 1 whereby p53 is present as a gene.

3. Use according to claim 1 whereby p53 is present as a protein.

4. Use according to one of the claims 1 to 3 in the form of a topical composition.

5. Use according to one of the claims 1 to 3 in the form of a pharmaceutical composition.

6. Use according to one of the claims 1 to 3 in the form of a nutritional composition.

7. Use according to one of the claims 1 to 4, characterised in that at least one compound used according to claim 1 is present in a topical composition in an amount from 0.0001 to 50% wt. referred to the composition.

8. Use according to one of the claims 1 to 7, characterised in that (S)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid and/or (S, S)-1,4,5,6-tetrahydro-5-hydroxy-2-methyl-4-pyrimidine carboxylic acid are used.