Mineral-polymer hybrid composition
First Claim
1. An injectable self-setting composition comprising:
- a) a water-based liquid component comprising at least one cationic polymer and one mono-phosphate salt;
said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character and being free of insoluble particles; and
b) a powder component comprising at least two calcium phosphate sources selected from apatites and apatitic calcium phosphates, octacalcium phosphates, amorphous calcium phosphates, tetracalcium phosphates, tricalcium phosphates, dicalcium phosphates and monocalcium phosphates, wherein when said components of step a) and b) are intimately and uniformly mixed together, said components of step a) and b) form an injectable thermo-setting slurry, said slurry when heated turns into a solid material.
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Abstract
The present invention relates to self-setting compositions consisting in admixed liquid and solid components enable the formation of hardened bio-materials having a broad range of properties and performances. The present invention proposes a) a thermo-sensitive self-gelling liquid component, being water-based, comprising at least a polycationic and a phosphate source, wherein the liquid component is a thermo-gelling solution at a pH ranging from 6.5 to 7.4; b) a powder component consisting in at least two calcium phosphate sources. The preferred calcium phosphate source includes apatites, tricalcium phosphates, tetracalcium phosphates and dicalcium phosphates. Both solid and liquid components are admixed to form a flowable slurry that sets in situ into a hardened calcium phosphate based bio-material.
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Citations
57 Claims
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1. An injectable self-setting composition comprising:
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a) a water-based liquid component comprising at least one cationic polymer and one mono-phosphate salt;
said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character and being free of insoluble particles; and
b) a powder component comprising at least two calcium phosphate sources selected from apatites and apatitic calcium phosphates, octacalcium phosphates, amorphous calcium phosphates, tetracalcium phosphates, tricalcium phosphates, dicalcium phosphates and monocalcium phosphates, wherein when said components of step a) and b) are intimately and uniformly mixed together, said components of step a) and b) form an injectable thermo-setting slurry, said slurry when heated turns into a solid material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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42. An injectable self-setting composition comprising:
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a) a liquid component, free of insoluble material, comprising, an organic and/or inorganic acid, a partially N-deacetylated chitosan and/or a collagen, and a glycerophosphate;
said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character, said partially N-deacetylated chitosan having a final concentration ranging between 0.5 to 3.0% w/v, and said glycerophosphate salt having a final concentration ranging between 1.0 to 10.0% w/v, andb) a powder component comprising a dry mixture of a tricalcium phosphate with a calcium deficient apatite or an octacalcium phosphate, and with at least one of an inorganic salt, an organic salt, an organic acid source and an organic compound, wherein when said components of step a) and b) are intimately and uniformly mixed together, said components of step a) and b) form an injectable thermo-setting slurry, said slurry when heated turns into a solid material. - View Dependent Claims (44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
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43. An injectable self-setting composition comprising:
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a) a liquid component, free of insoluble particle, comprising an organic and/or inorganic acid, a partially N-deacetylated chitosan and/or a collagen, and a glycerophosphate;
said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character, said partially N-deacetylated chitosan has a concentration ranging between 0.5 to 3.0% w/v, and said glycerophosphate salt has a concentration ranging between 1.0 to 10.0% w/v, andb) a powder component comprising a dry mixture of a tetracalcium phosphate with a calcium deficient apatite or an octacalcium phosphate, and with at least one of an inorganic salt, an organic salt, an organic acid source and an organic compound, wherein when said components of step a) and b) are intimately and uniformly mixed together, said components of step a) and b) form an injectable thermo-setting slurry, said slurry once heated setting into a solid material.
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55. A method of preparation of an injectable self-setting composition, said method comprising the step of admixing a water-based liquid component comprising at least one cationic polymer and one monophosphate salt with a powder component comprising at least two calcium phosphate sources selected from apatites and apatitic calcium phosphates, octacalcium phosphates, amorphous calcium phosphates, tetracalcium phosphates, tricalcium phosphates, dicalcium phosphates and monocalcium phosphates, wherein said liquid component comprising at least one cationic polymer and one mono-phosphate salt;
- said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character and being free of insoluble particles, said admixing thus forming an injectable thermo-setting slurry, said slurry when heated turns into a solid material.
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56. A method of preparation of an injectable self-setting composition, said method comprising admixing a liquid component, free of insoluble material, comprising, an organic and/or inorganic acid, a partially N-deacetylated chitosan and/or a collagen, and a glycerophosphate, with a powder component comprising a dry mixture of a tricalcium phosphate with a calcium deficient apatite or an octacalcium phosphate, and with at least one of an inorganic salt, an organic salt, an organic acid source and an organic compound, said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character, said partially N-deacetylated chitosan having a final concentration ranging between 0.5 to 3.0% w/v, and said glycerophosphate salt having a final concentration ranging between 1.0 to 10.0% w/v, said admixing thus forming an injectable thermo-setting slurry, said slurry when heated turns into a solid material.
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57. A method of preparation of an injectable self-setting composition, said method comprising admixing a liquid component, free of insoluble particle, comprising an organic and/or inorganic acid, a partially N-deacetylated chitosan and/or a collagen, and a glycerophosphate with a powder component comprising a dry mixture of a tetracalcium phosphate with a calcium deficient apatite or an octacalcium phosphate, and with at least one of an inorganic salt, an organic salt, an organic acid source and an organic compound, said liquid component having a pH ranging from 6.5 to 7.4, said liquid component having an endothermally gelling character, said partially N-deacetylated chitosan has a concentration ranging between 0.5 to 3.0% w/v, and said glycerophosphate salt has a concentration ranging between 1.0 to 10.0% w/v, said admixing thus forming an injectable thermo-setting slurry, said slurry when heated turns into a solid material.
Specification