Method and apparatus for penetrating tissue
First Claim
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1. A skin penetrating system, comprising:
- a housing member;
a penetrating member positioned in the housing member, and an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber, wherein a tip of the penetrating member is configured to extend through an opening of the sample chamber.
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Abstract
A skin penetrating system includes a housing member and a penetrating member positioned in the housing member. An analyte detecting member is coupled to a sample chamber. The analyte detecting member is configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μL of a body fluid disposed in the sample chamber. A tip of the penetrating member is configured to extend through an opening of the sample chamber.
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Citations
181 Claims
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1. A skin penetrating system, comprising:
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a housing member;
a penetrating member positioned in the housing member, and an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber, wherein a tip of the penetrating member is configured to extend through an opening of the sample chamber. - View Dependent Claims (2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 128, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140)
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3. A skin penetrating system, comprising:
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a housing member;
a plurality of penetrating members positioned in the housing member, and a plurality of analyte detecting members each associated with a penetrating member and a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber, wherein a tip of the penetrating member is configured to extend through an opening of a sample chamber.
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72. A tissue penetrating system, comprising:
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a penetrating member driver;
a cartridge with a distal port and a proximal port and coupled to the penetrating member driver;
an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber; and
a penetrating member with a sharpened distal tip and shaft portion that is slidably disposed within the cartridge, wherein a tip of the penetrating member is configured to extend through the opening of the sample chamber. - View Dependent Claims (116, 117, 118, 119, 120)
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122. The system of claim 121, wherein the tissue stabilizer device is configured to enhance fluid flow from a target tissue.
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123. The system of claim 121, wherein the tissue stabilizer device creates a stretching of a skin surface.
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124. The system of claim 1, further comprising:
a tissue stabilizer device coupled to the housing.
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124-1. The system of claim 121, wherein the tissue stabilizer device includes a plurality of protrusions.
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125. The system of claim 121, wherein the tissue stabilizer device applies a vacuum to a target tissue.
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126. The system of claim 121, wherein the tissue stabilizer device is configured to apply a force to a target tissue and cause the target tissue to press in an inward direction relative to the housing member.
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127. The system of claim 121, wherein the tissue stabilizing member applies a stimulation to a target tissue.
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129. The system of claim 121, further comprising
a second fracturable seal located at least one of the distal port or proximal port of cartridge.
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141. A tissue penetrating system, comprising:
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a penetrating member driver;
a cartridge with a distal port and a proximal port and coupled to the penetrating member driver;
an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber;
a penetrating member with a sharpened distal tip and shaft portion that is slidably disposed within the cartridge, wherein a tip of the penetrating member is configured to extend through the opening of the analyte detecting member; and
a first seal formed at the distal port and a second seal formed at the proximal port, wherein the first seal and second seal maintain the distal tip of the penetrating member and the sample chamber in a sterile environment prior to launch of the penetrating member. - View Dependent Claims (142, 143, 144, 145, 146, 147, 148)
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149. A tissue penetrating system, comprising:
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a cartridge with a distal port and a proximal port, each cartridge including an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber;
a penetrating member with a sharpened distal tip and shaft portion that is slidably disposed within the cartridge;
a first seal covering the distal port; and
a second seal covering the proximal port - View Dependent Claims (150, 151, 152, 153, 154, 155, 156)
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157. A tissue penetrating system, comprising:
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a plurality of penetrating members each having a sharpened distal tip;
a penetrating member driver coupled to the plurality of penetrating members; and
a plurality of cartridges each housing a penetrating member and configured so that the penetrating member driver engages each of the penetrating members sequentially, each cartridge including an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber. - View Dependent Claims (158, 159, 160, 161, 162, 163, 164, 165)
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166. A tissue penetrating system, comprising:
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a plurality of cartridges, each cartridge including an analyte detecting member coupled to a sample chamber, the analyte detecting member being configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μ
L of a body fluid disposed in the sample chamber; and
each of the cartridges having a plurality of seals positioned so that the sample chamber remains in a sterile environment before launch of a penetrating member, the plurality of modules coupled together in an array. - View Dependent Claims (167, 168, 169, 170, 171, 172, 173, 174)
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175. A method of penetrating a target tissue, comprising:
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providing a tissue penetrating system with a penetrating member and an analyte detecting member coupled to a sample chamber,;
advancing a penetrating member through the target tissue;
withdrawing the penetrating member from the target tissue. receiving no more than 1 μ
L of a body fluid in the sample chamber. - View Dependent Claims (176, 177, 178, 179, 180, 181)
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Specification