Method and apparatus for the transdermal administration of a substance
First Claim
1. A delivery device for introducing a substance into the skin of a patient for delivering the substance to the patient, said device comprising:
- a top wall having at least one opening;
a bottom wall coupled to said top wall and spaced from said top wall to define a reservoir therebetween for containing said substance, said bottom wall having a plurality of openings;
a coupling member attached to said top wall for supplying said substance through said openings in said top wall and into said reservoir; and
a plurality of microneedles coupled to said outer surface of said bottom wall and being in communication with said openings in said bottom wall for directing said substance from said reservoir into the skin of a patient.
1 Assignment
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Accused Products
Abstract
A transdermal delivery device includes a plurality of microneedles for injecting a substance such as a pharmaceutical agent into or below the stratum corneum of the skin. The device has housing formed from a top and bottom wall to define a chamber for containing a pharmaceutical agent. An inlet port is provided in the top wall of the housing for supplying the pharmaceutical agent to the chamber and directing the agent to the microneedles. The housing can have a Luer lock type fitting for coupling with a syringe having a Luer lock collar to inject the pharmaceutical agent into the housing. The housing can be divided into a plurality of chambers by an internal wall for supplying different agents simultaneously or sequentially to a patient. The microneedles have a length of about 5-250 microns and generally about 50-100 microns.
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Citations
30 Claims
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1. A delivery device for introducing a substance into the skin of a patient for delivering the substance to the patient, said device comprising:
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a top wall having at least one opening;
a bottom wall coupled to said top wall and spaced from said top wall to define a reservoir therebetween for containing said substance, said bottom wall having a plurality of openings;
a coupling member attached to said top wall for supplying said substance through said openings in said top wall and into said reservoir; and
a plurality of microneedles coupled to said outer surface of said bottom wall and being in communication with said openings in said bottom wall for directing said substance from said reservoir into the skin of a patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A device for administering a substance to the skin of a patient comprising:
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a substantially planar base having a top surface, a bottom surface and an opening extending between said top and bottom surfaces;
a coupling member attached to said top surface of said base for directing said substance through said openings in said base and for coupling to a fluid source;
a plurality of microneedles attached to and extending from said bottom surface of said base; and
a plurality of channels formed in said bottom surface of said base and extending outwardly from said opening and being positioned between said microneedles. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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21. A delivery device for delivering a substance into a patient comprising:
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a syringe having a syringe barrel with an outlet tip and a plunger for dispensing said substance contained in said syringe; and
a plurality of microneedles coupled to said outlet tip and having a channel extending through the microneedles for delivering the substance to a patient. - View Dependent Claims (22)
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23. A method of administering a substance through the skin of a patient comprising:
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providing a device having a body with a top surface, a bottom surface and at least one opening extending between said top and bottom surfaces;
a plurality of microneedles attached to and extending from said bottom surface of said body;
contacting said device with the skin of a patient and applying sufficient pressure for said microneedles to pierce the stratum corneum of said patient; and
delivering a substance to said microneedles for delivery through the skin. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30)
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Specification