Anti-inflammatory biosensor for reduced biofouling and enhanced sensor performance

• US 20030199837A1
• Filed: 04/22/2002
• Published: 10/23/2003
• Est. Priority Date: 04/22/2002
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Vachon, David J.
• Granted Patent: US 7,153,265 B2
• Time in Patent Office: Days
• US Class Current: 604/289
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: C12Q 1/006 for glucose

Abstract

A biosensor including an external surface, and an accessory material in close proximity to the external surface. The accessory material includes a coating containing a hydrophilic material and/or a fiber modified to deliver a therapeutic agent. The biosensor modifies a biological response to the biosensor upon contact with a tissue, such as upon implantation into the skin of a subject, thereby reducing biofouling, inflammation and other undesirable tissue responses that interfere with biosensor performance. The biosensor can be any biocompatible sensor, suitable for short- or long-term use. Preferably, the biosensor is an enzymatic or electrochemical sensor, such as a glucose sensor. Also provided are a method of producing a biosensor and a method of delivering a biologically active substance to a subject.

Claims

1. A biosensor comprising a sensor having an external surface, and an accessory material provided in proximity to the external surface, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor.

2. The biosensor of claim 1, wherein the biological response comprises protein deposition, inflammation or proliferation of macrophages or foreign body giant cells.

3. The biosensor of claim 1, wherein the accessory material comprises a hydrophilic polymer.

4. The biosensor of claim 3, wherein the hydrophilic polymer comprises polyhydroxyethylmethacrylate (PHEMA), polyurethane, polysaccharide, polyacrylamide, or polyurea.

5. The biosensor of claim 3, wherein the hydrophilic polymer comprises polyethylene oxide (PEO).

6. The biosensor of claim 5, wherein the PEO comprises a polyurethane, polyurea or a cross-linked PEO.

7. The biosensor of claim 1, wherein the coating further comprises an anti-inflammatory agent.

8. The biosensor of claim 7, wherein the anti-inflammatory agent comprises dexamethasone or a salt thereof.

9. The biosensor of claim 8, wherein the salt is a sodium phosphate or acetate salt.

10. The biosensor of claim 1, which comprises an enzymatic, molecular recognition, optochemical or electrochemical sensor.

11. The biosensor of claim 1, which comprises a glucose sensor.

12. The biosensor of claim 1, wherein the accessory material comprises a fiber modified to deliver a therapeutic agent.

13. The biosensor of claim 12, wherein the fiber comprises cotton, polypropylene, polyurethane, polyester, polylactic acid (PLA), polyglycolic acid (PGA), or a co-polymer of lactic acid and glycolic acid (PLGA).

14. The biosensor of claim 12, wherein the therapeutic agent comprises an anti-inflammatory, anti-bacterial, anti-viral, anti-coagulant, anti-proliferative or disinfecting agent, or a growth factor.

15. The biosensor of claim 14, wherein the therapeutic agent comprises dexamethasone, cefazolin or benzalkonium chloride.

22. A method of delivering a biologically active substance to a subject comprising implanting a biosensor of claim 1 into a tissue of the subject, wherein the accessory material comprises the biologically active substance.

23. The method of claim 22, wherein the biologically active substance comprises a cytokine, growth factor or therapeutic agent.

16. A method of producing a biosensor comprising providing an accessory material in close proximity to the biosensor, wherein the accessory material modifies the biological response of a tissue that is in contact with the biosensor.

17. The method of claim 16, wherein the provision of an accessory material comprises coating the sensor with a hydrophilic polymer.

18. The method of claim 17, wherein the polymer comprises a polyurethane, acrylate, polyester or cross-linked PEO.

19. The method of claim 17, wherein the coating comprises spraying or painting the polymer onto the sensor.

20. The method of claim 16, wherein the accessory material comprises a fiber modified to deliver a therapeutic agent.

21. A biosensor produced by the method of claim 16.