Drug releasing biodegradable fiber implant
First Claim
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1. An implant composition comprising a scaffold comprising biodegradable polymer fibers, said fibers containing one or more therapeutic agent that are released over time.
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Abstract
The invention provides tissue engineering compositions and methods wherein three-dimensional matrices for growing cells are prepared for in vitro and in vivo use. The matrices comprise biodegradable polymer fibers capable of the controlled delivery of therapeutic agents. The spatial and temporal distribution of released therapeutic agents is controlled by use of defined nonhomogeneous patterns of therapeutic agents in the matrices.
110 Citations
198 Claims
- 1. An implant composition comprising a scaffold comprising biodegradable polymer fibers, said fibers containing one or more therapeutic agent that are released over time.
- 17. A drug-delivery fiber composition comprising one or more biodegradable polymer fibers containing one or more therapeutic agents, wherein the content of said one or more therapeutic agents within said fiber varies along the longitudinal axis of said fiber such that the content of said one or more therapeutic agents decreases from the first end of said fiber to the second end of said fiber.
- 19. A method of controlling the spatial and temporal concentration of one or more therapeutic agents within a fiber-scaffold implant, comprising implanting a fiber-scaffold into a host, wherein said fiber-scaffold comprises biodegradable polymer fibers containing one or more therapeutic agents, wherein said one or more therapeutic agents are distributed in said fiber-scaffold in a defined nonhomogeneous pattern, which may or may not be homogeneous with regard to fiber type and distribution.
- 35. A method of preparing a fiber-scaffold for preparing an implant capable of controlling the spatial and temporal concentration of one or more therapeutic agents, comprising providing biodegradable polymer fibers containing one or more therapeutic agents and forming said biodegradable polymer fibers into a three dimensional fiber-scaffold, wherein said one or more therapeutic agents are distributed in said fiber-scaffold in a defined nonhomogeneous pattern, which may or may not be homogeneous with regard to fiber type or biological material content.
- 51. A method of creating a drug releasing fiber from chitosan comprising use of hydrochloric acid as a solvent and Tris base as a coagulating bath.
- 79. A method of creating a drug releasing fiber comprising adding poly(L-lactic acid) microspheres loaded with drug or proteins as a drug delivery reservoir to a solution of chitosan in acid and using a sodium hydroxide coagulation bath.
- 89. A composition comprising a fiber containing chitosan and an extracellular matrix.
- 91. A composition comprising a three-dimensional scaffold, said scaffold comprising fibers that are woven, non-woven, or knitted, or braided wherein said fibers comprise a composition comprising a fiber containing chitosan and an extracellular matrix.
- 93. A composition comprising fibers containing chitosan, extracellular matrix and a biological molecule.
- 96. A composition of chitosan fibers comprising microspheres of a second polymer, said microspheres comprising one or more biological molecules.
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101. A method of fabricating fibers, comprising:
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a) obtaining a water-in-oil type emulsion comprising an aqueous phase containing an active biomolecule and a surfactant in a biodegradable polymer solution; and
b) extruding said emulsion into a coagulating bath. - View Dependent Claims (102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120)
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121. A method of fabricating fibers with a linear gradient of bioactive molecules, said method comprising:
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a) obtaining a first polymer solution and a second polymer solution; and
b) mixing said first polymer solution and said second polymer solution in a continuously changing ratio to obtain a mixture of said first and second polymer solutions, while extruding said mixture into a coagulating bath. - View Dependent Claims (122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 185, 186, 187, 188)
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144. A method of creating drug-releasing fibers, said method comprising obtaining a polymer solution comprising a synthetic biodegradable polymer in a solvent;
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adding biomolecule loaded NIPA gels to the polymer solution; and
extruding the polymer solution into a coagulating bath comprising at least one solvent wherein the polymer solvent is substantially immiscible with water and highly miscible with the coagulating bath solvent. - View Dependent Claims (145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 184)
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157. A method of creating a drug releasing fiber from chitosan, said method comprising:
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a) obtaining a polymer solution comprising chitosan and a hydrochloric acid; and
b) extruding the polymer solution into a coagulating bath comprising tris base. - View Dependent Claims (158, 159, 160, 161)
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- 176. A composition of parallel fibers bundled in a circular cross section for the treatment of lesions in the nervous system wherein at least some of the fibers are loaded with a neurotrophin.
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179. A composition for treating lesions of the digestive system, comprising fibers loaded with one or more biomolecule induction of epithelial cells, smooth muscle cells etc., into a tubular shaped scaffold.
- 180. A composition for treating lesions of the musculoskeletal system, comprising a scaffold comprising fibers in parallel arrays for the induction and alignment of musculoskeletal cells.
- 190. A composition of a coaxial fiber comprising a first segment and a second segment, wherein the first segment comprises an inert sealant and the second segment contains at least one biologically active molecule.
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198. A composition of fibers that release neurotrophins to the optical nerve when placed near the optical nerve.
Specification