Microarray channel devices produced by a block mold process
First Claim
1. A device comprising a plurality of parallel channels adjacent to other channels within a suitably shaped block at addressable locations with respect to each other wherein said channels are formed by removing a material from within a solid block thereby forming said channels, and further wherein said channels contain different agents of interest by immobilizing said agents within separate channels.
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Accused Products
Abstract
Microarrays are made from sections of a molded block having many channels. These channels, which are formed by casting and/or embedding a rod in a moldable solid, are used to immobilize biological and chemical binding components after rod removal. The microarrays can be used in general biological assays, clinical evaluations and chemical library analyses.
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Citations
30 Claims
- 1. A device comprising a plurality of parallel channels adjacent to other channels within a suitably shaped block at addressable locations with respect to each other wherein said channels are formed by removing a material from within a solid block thereby forming said channels, and further wherein said channels contain different agents of interest by immobilizing said agents within separate channels.
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10. A method of forming a device comprising a plurality of parallel channels adjacent to other channels within a suitably shaped block at addressable locations with respect to each other wherein said channels are formed by removing a material to form said channels, and further wherein said channels contain different agents of interest by immobilizing said agents within each separate channel by means of said removal comprising:
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(a) embedding a plurality of solid materials in a moldable surface of a blocking forming material;
(b) removing said solid materials embedded in a block to form the channels; and
(c) adhering, adsorbing or linking at least one agent of interest to the inside of the channel of step (b). - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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27. A method of forming a device comprising a plurality of parallel channels adjacent to other channels within a suitably shaped block at addressable locations with respect to each other wherein said channels are formed by removing solid material to form said channels, and further wherein said channels contain different agents of interest by immobilizing said agents within each separate channel by means of said removal comprising:
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(a) removing said solid materials from said block to form the channels and (b) adhering, adsorbing or linking at least one agent of interest to the inside of the channel of step (a). - View Dependent Claims (28, 29, 30)
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Specification