Micro arrays with structured and unstructured probes
First Claim
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1. A micro array for binding a target, comprising:
- (a) a substrate surface;
(b) an unstructured probe attached to said substrate surface for binding to said target and providing a first signal;
(c) a structured probe attached to said substrate surface for providing a second signal; and
(d) a light source for providing excitation of said unstructured and structured probes wherein said unstructured probe provides said first signal and said structured probe provides said second signal and wherein said first signal produced by said unstructured probe can be compared to said second signal produced by said structured probe and a more accurate reading of said first signal can be determined for said unstructured probe.
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Abstract
The invention provides an apparatus and method for determining a signal produced by a micro array device. The apparatus provides an unstructured probe and structured probe. The unstructured probe binds to a target and provides a first signal that can be compared to a second signal produced by a structured probe. A more accurate level of intensity of the first signal can be determined by comparing to the second signal produced by the structured probe. A method for determining a more accurate level of signal intensity produced from the unstructured probes bound to the target is also disclosed.
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Citations
19 Claims
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1. A micro array for binding a target, comprising:
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(a) a substrate surface;
(b) an unstructured probe attached to said substrate surface for binding to said target and providing a first signal;
(c) a structured probe attached to said substrate surface for providing a second signal; and
(d) a light source for providing excitation of said unstructured and structured probes wherein said unstructured probe provides said first signal and said structured probe provides said second signal and wherein said first signal produced by said unstructured probe can be compared to said second signal produced by said structured probe and a more accurate reading of said first signal can be determined for said unstructured probe. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for determining a more accurate reading of a first signal produced by an unstructured probe attached to a micro array substrate surface, comprising:
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(a) illuminating an unstructured probe attached to a target on said micro array substrate surface to produce a first signal;
(b) illuminating a structured probe attached to said micro array substrate surface to produce a second signal; and
(c) comparing said first signal produced from said unstructured probe bound to said target, to said second signal produced from said structured probe attached to said micro array substrate surface to determine a more accurate signal intensity reading of said first signal.
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19. A method for determining a level of signal intensity produced by an unstructured probe attached to a micro array, comprising:
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(a) providing a first light source for illuminating an unstructured probe attached to a target on said micro array to produce a first signal;
(b) providing a second light source for illuminating a structured probe on said micro array to produce a second signal; and
(c) comparing said first signal intensity produced from said unstructured probe attached to said target to said second signal intensity level produced from said structured probe attached to said micro array substrate surface to calibrate an improved signal intensity level of said first signal.
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Specification