Inhibition of pathogen replication by RNA interference
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Abstract
A method and composition for the treatment of pathogenic diseases was developed using the mechanism of RNA interference. The method uses double-stranded RNA to activate the RNA interference pathways within mammalian or pathogen cells. The method can be used to treat any diseases which are caused by or associated with pathogens. A method for identifying double-stranded RNAs useful for the treatment of pathogenic diseases is also presented, as well as model systems which allow this identification. Also described are methods in which siRNAs are used for the inhibition of HIV replication in human cells, as well as the inhibition of RSV pathogenesis in chick embryos.
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