Implantable electroporation therapy device and method for using same
First Claim
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1. An electroporation device for implantation within a body, the device comprising:
- a housing;
at least one lead extending from the housing, the at least one lead having a therapy electrode associated therewith, the therapy electrode operable to selectively electroporate tissue within the body; and
logic and control circuitry located within the housing and operable to control the therapy electrode.
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Abstract
IMDs and methods are provided for electroporation treatment of subcutaneous tumors. In some embodiments, IMDs of the present invention may store and introduce chemotherapy drugs into the body prior to electroporation therapy. High frequency stimulation of tissue in or around the tumor may also be provided to increase tissue temperature prior to electroporation therapy. Still further, delivery of the electroporation therapy may be synchronized with cardiac qRs complex to avoid impeding normal cardiac rhythm. Algorithms to suspend therapy in the event of edema may also be incorporated.
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Citations
83 Claims
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1. An electroporation device for implantation within a body, the device comprising:
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a housing;
at least one lead extending from the housing, the at least one lead having a therapy electrode associated therewith, the therapy electrode operable to selectively electroporate tissue within the body; and
logic and control circuitry located within the housing and operable to control the therapy electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. An electroporation treatment device for implantation within a body, the device comprising:
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a housing;
at least one lead extending from the housing, the at least one lead having a therapy electrode located proximate a distal end of the at least one lead, the therapy electrode operable to selectively electroporate tissue within the body;
logic and control circuitry located within the housing and operable to control the therapy electrode; and
a drug catheter associated with the housing, the drug catheter operable to deliver a drug to the body under control of the logic and control circuitry. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. An electroporation treatment device for implantation within a body, the device comprising:
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a housing;
a first lead extending from the housing, the first lead having a first therapy electrode located proximate a distal end of the first lead;
a second lead extending from the housing, the second lead having a second therapy electrode located proximate a distal end of the second lead, wherein one or both of the first therapy electrode and the second therapy electrode are operable to selectively electroporate tissue within the body; and
logic and control circuitry located within the housing and operable to control one or both of the first therapy electrode and the second therapy electrode. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A method for treating a cancerous tumor, comprising:
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implanting an electroporation device in a body;
delivering a drug to the body and proximate the cancerous tumor; and
delivering, with the electroporation device, at least one electrical pulse across at least a portion of the cancerous tumor. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57)
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58. A method for treating cancer, comprising:
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implanting an electroporation device in a body, the electroporation device operable to selectively electroporate tissue within the body using at least one lead having a therapy electrode associated therewith; and
locating the therapy electrode in or proximate a cancerous tumor;
applying a high frequency stimulus in the vicinity of the cancerous tumor with the at least one therapy electrode, thereby raising a temperature in the vicinity of the cancerous tumor;
delivering a drug to the body in the vicinity of the cancerous tumor; and
delivering, with the electroporation device, at least one electrical pulse in the vicinity of the cancerous tumor. - View Dependent Claims (59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71)
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72. A method for treating cancer, comprising:
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implanting an electroporation device in a body, the electroporation device operable to selectively electroporate tissue within the body using at least one lead having a therapy electrode associated therewith;
sensing a temperature in the body and providing a sense signal based upon the temperature;
locating the therapy electrode in or proximate a tumor;
delivering a drug to the body;
applying a high frequency stimulus in the vicinity of the tumor with the therapy electrode, thereby raising a temperature in or around the tumor to at least a threshold temperature; and
delivering, with the electroporation device, at least one electrical pulse in the vicinity of the tumor. - View Dependent Claims (73, 74, 75, 76, 77, 78, 79, 80, 81)
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82. A system for treating a cancerous tumor within a body, the system comprising:
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an implantable and programmable electroporation device, comprising;
a housing;
at least one lead extending from the housing, the at least one lead having a therapy electrode associated therewith, the therapy electrode operable to selectively electroporate tissue within the body;
logic and control circuitry located within the housing and operable to control the therapy electrode; and
first telemetry circuitry associated with the logic and control circuitry; and
an external programming device, comprising;
programming circuitry operable for use in programming the implantable and programmable electroporation device; and
second telemetry circuitry associated with the programming circuitry, wherein the second telemetry circuitry is operable to communicate with the first telemetry circuitry to permit programming of the implantable and programmable electroporation device. - View Dependent Claims (83)
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Specification