Implantable medical device having biologically active polymeric casing
First Claim
1. An implantable medical device, comprising:
- a medical unit; and
a casing at least partially enclosing the medical unit, the casing being formed of a base polymer selected from the group consisting of polyurethanes, polyurethane copolymers, fluoropolymers, polyolefins, epoxies and silicone rubbers, the casing having polyethylene oxide surface modifying end groups covalently bonded to the base polymer, the casing having and biologically active agents attached to the surface modifying end groups, the biologically active agents being selected from the group consisting of microbial peptide agents, antimicrobials, antibiotics, detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids and fatty acid salts.
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Accused Products
Abstract
An implantable medical device has a medical unit, such as a pacemaker lead, and a casing at least partially enclosing the medical unit. The casing is formed of a base polymer such as a polyurethane, a polyurethane copolymer, a fluoropolymer and a polyolefin or a silicone rubber. The casing has biologically active agents covalently bonded to the base polymer. The biologically active agents can be attached to the base polymer as surface active end groups. As an alternative, the biologically active may be attached to a backbone the base polymer. As yet a further alternative, the biologically active agents may be attached to surface modifying end groups, which are in turn attached to the base polymer. Examples of suitable biologically active agents are microbial peptide agents, detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids and fatty acid salts.
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Citations
22 Claims
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1. An implantable medical device, comprising:
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a medical unit; and
a casing at least partially enclosing the medical unit, the casing being formed of a base polymer selected from the group consisting of polyurethanes, polyurethane copolymers, fluoropolymers, polyolefins, epoxies and silicone rubbers, the casing having polyethylene oxide surface modifying end groups covalently bonded to the base polymer, the casing having and biologically active agents attached to the surface modifying end groups, the biologically active agents being selected from the group consisting of microbial peptide agents, antimicrobials, antibiotics, detergents, non-steroidal anti-inflammatory drugs, cations, amine-containing organosilicones, diphosphonates, fatty acids and fatty acid salts.
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2. An implantable medical device, comprising:
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a medical unit; and
a casing at least partially enclosing the medical unit, the casing being formed of a base polymer and biologically modifying agents attached to the base polymer as surface active end groups. - View Dependent Claims (3, 4, 5, 6, 7)
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8. An implantable medical device, comprising:
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a medical unit; and
a casing at least partially enclosing the medical unit, the casing being formed of a base polymer and biologically active agents attached to a backbone of the base polymer. - View Dependent Claims (9, 10, 11, 12, 13)
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14. An implantable medical device, comprising:
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a medical unit; and
a casing at least partially enclosing the medical unit, the casing being formed of a base polymer having surface modifying end groups, the casing having biologically modifying agents attached to the surface modifying end groups. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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Specification