Novel topical compositions

• US 20030206932A1
• Filed: 08/07/2002
• Published: 11/06/2003
• Est. Priority Date: 09/07/1994
• Status: Abandoned Application

• Current Assignee: Christopher R. Stahl, Curtis A. Cole, Jean P. Holland, Jonas C.T. Wang, Jue-Chen Liu, Kamran Mather, Margaret A. Aleles, Mohammed Yusuf, Norihiro Yamamoto, Sachio Hamada, Satoshi Kazama, Stephen J. Wisniewski
• Original Assignee: Christopher R. Stahl, Curtis A. Cole, Jean P. Holland, Jonas C.T. Wang, Jue-Chen Liu, Kamran Mather, Margaret A. Aleles, Mohammed Yusuf, Norihiro Yamamoto, Sachio Hamada, Satoshi Kazama, Stephen J. Wisniewski
• Inventors: Yamamoto, Norihiro, Liu, Jue-Chen, Kazama, Satoshi, Yusuf, Mohammed, Wang, Jonas C. T., Holland, Jean P., Hamada, Sachio, Aleles, Margaret A., Stahl, Christopher R., Mather, Kamran, Cole, Curtis A., Wisniewski, Stephen J.
• Application Number:
  US10/213,714
• Publication Number:
  US 20030206932A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/51 Chelating agents
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 2800/75 Anti-irritant
• CPC Class Codes: A61K 2800/88 Two- or multipart kits
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/062 Oil-in-water emulsions
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin

Abstract

Skin care compositions comprising an oil-in-water emulsion base containing retinoids and possessing good physical and chemical stability

Claims

1. A skin care composition comprising an oil-in-water emulsion and a retinoid selected from the group consisting of Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof, said composition having a pH of between about 4 and about 10;

said composition further comprising an oil phase, said oil phase having a relatively low level of unsaturation;

said composition further comprising a stabilizing system selected from the group consisting of;

a) at least one oil-soluble antioxidant;

b) a chelating agent and at least one oil-soluble antioxidant;

c) a chelating agent; and

d) a chelating agent and an antioxidant present in each of the oil and water phases of said emulsion;

said composition retaining at least about 70% of said retinoids after 13 weeks'"'"' storage at 40°

C.

14. A skin care composition according to claim 1 which further comprises an irritation mitigating oil phase present in an irritation mitigation-effective amount.

16. A skin care composition according to claim 1 which further comprises an irritation mitigation agent present in an irritation mitigation-effective amount.

2. An oil-in-water emulsion composition comprising:

a) an emulsifier system selected from the group consisting of;

i) a mixture of glyceryl stearate and polyethylene glycol 100 stearate;

ii) cetearyl alcohol and cetearyl glucoside;

iii) a mixture of a polyethylene glycol ether of stearyl alcohol of the formula;

CH(CH₂)₁₆CH₂(OCH₂CH₂)_nOH

 

wherein n is 21 and a polyethylene glycol ether of stearyl alcohol of the formula;

CH₃ (CH₂)₁₆CH₂ (OCH₂CH₂)_nOH

 

wherein n is 2; and

iv) a mixture of sorbitan stearate and polysorbate 60 (a mixture of stearate esters of sorbitol and sorbitol anhydrides condensed with 20 moles of ethylene oxide);

b) a co-emulsifier selected from the group consisting of;

cetyl alcohol, stearyl alcohol and mixtures thereof;

c) an oil phase present in the amount of from about 5 to about 20 percent by weight of the total emulsion composition comprising;

i) a light, dry absorbable oil and

ii) substantive, emollient oils or waxes wherein said light dry absorbable oil and said substantive oil or wax are present in a ratio of from about 1;

3 to about 10;

1.

15. A skin care composition according to claim 2 which further comprises an irritation mitigating oil phase present in an irritation mitigation-effective amount.

17. A skin care composition according to claim 2 which further comprises an irritation mitigation agent present in an irritation mitigation-effective amount.

3. A skin care composition comprising (a) a retinoid selected from the group consisting of Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof, and (b) an irritation mitigating oil phase present in an irritation mitigation-effective amount.

4. A skin care composition according to claim 3 wherein said irritation mitigating oil phase comprises one or more components whose composite solubility parameter δ

is within 2 units of the solubility parameter of the retinoid in the composition.

5. A skin care composition according to claim 4 wherein said irritation mitigating oil phase comprises one or more components whose composite solubility parameter is within 1.5 units of the solubility parameter of the retinoid in the composition.

6. A skin care composition according to claim 5 wherein said irritation mitigating oil phase comprises one or more components whose composite solubility parameter is within 1 unit of the solubility parameter of the retinoid in the composition.

7. A skin care composition comprising (a) a retinoid selected from the group consisting of Vitamin A alcohol, Vitamin A aldehyde, retinyl acetate, retinyl palmitate and mixtures thereof, and (b) an irritation mitigation agent present in an irritation mitigation-effective amount.

8. A skin care composition according to claim 7 wherein said irritation mitigation agent comprises an oil soluble compound having a carbon chain of at least about 12 carbon atoms.

9. A skin care composition according to claim 7 wherein said irritation mitigation agent comprises an ester compound.

10. A skin care composition according to claim 9 wherein said irritation mitigation agent comprises an ester of a fatty alcohol.

11. A skin care composition according to claim 9 wherein said irritation mitigation agent comprises an ester of a fatty acid.

12. A skin care composition according to claim 10 wherein said irritation mitigation agent is selected from the group consisting of:

C_12-15 Alkyl benzoate, octyl methoxycinnamate, octyl dimethyl PABA, octocrylene, menthyl anthranilate, homomenthyl salicylate, glyceryl stearate, PEG 100 stearate, and stearyl lactate or a mixture thereof.

13. A skin care composition according to claim 10 wherein said irritation mitigation agent is selected from the group consisting of, cetyl alcohol, stearyl alcohol or a mixture thereof.