Fibrinogen binding moieties
First Claim
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1. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
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Abstract
Compositions comprising non-naturally occurring fibrinogen binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating fibrinogen molecules in a solution, for blood circulation imaging, and for linking therapeutics or other molecules to fibrinogen. Preferred binding peptides having a high affinity for fibrinogen are particularly disclosed.
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43 Claims
- 1. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
- 4. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
- 7. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
- 10. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
- 13. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
- 16. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
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18. A fibrinogen binding moiety comprising a polypeptide comprising an amino acid sequence of the formula:
Specification