Electropancreatography

• US 20030208242A1
• Filed: 05/05/2003
• Published: 11/06/2003
• Est. Priority Date: 05/31/2000
• Status: Abandoned Application

• Current Assignee: Impulse Dynamics NV
• Original Assignee: Impulse Dynamics NV
• Inventors: Darvish, Nissim, Mika, Yuval, Felsen, Bella, Levi, Tamir, Glassberg, Offer, Harel, Tamar
• Application Number:
  US10/296,668
• Publication Number:
  US 20030208242A1
• Time in Patent Office: Days
• US Class Current: 607/40
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/425 pancreas
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61N 1/08 Arrangements or circuits for monitoring, protecting, controlling or indicating for external stimulators A61N1/3603; for implantable neurostimulators A61N1/36128; for heart stimulators A61N1/37; for defibrillators A61N1/3925
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02

Abstract

Apparatus (18) for sensing electrical activity of a pancreas (20) of a patient is provided. The apparatus includes a set of one or more electrodes (100), adapted to be coupled to the pancreas, and a control unit (90), adapted to receive electrical signals from the electrodes indicative of electrical activity of pancreatic cells which are in a plurality of islets of the pancreas, and to generate an output responsive thereto.

Claims

1. Apparatus for sensing electrical activity of a pancreas of a patient, comprising:

a set of one or more electrodes, adapted to be coupled to the pancreas; and

a control unit, adapted to receive electrical signals from the electrodes indicative of electrical activity of pancreatic cells which are in a plurality of islets of the pancreas, and to generate an output responsive thereto.

2. Apparatus according to claim 1, wherein a single electrode in the set of one or more electrodes is adapted to convey to the control unit an electrical signal indicative of electrical activity of pancreatic cells which are in two or more of the islets.

3. Apparatus according to claim 1, wherein the control unit is adapted to receive electrical signals from the electrodes indicative of electrical activity of pancreatic cells which are in five or more of the islets.

4. Apparatus according to claim 1, wherein the control unit is adapted to receive electrical signals from the electrodes indicative of electrical activity of pancreatic cells which are in ten or more of the islets.

5. Apparatus according to claim 1, wherein a first one of the one or more electrodes is adapted to convey to the control unit a first electrical signal, indicative of electrical activity of pancreatic cells which are in a first one of the islets, and wherein a second one of the one or more electrodes is adapted to convey to the control unit a second electrical signal, indicative of electrical activity of pancreatic cells which are in a second one of the islets, which is different from the first one of the islets.

6. Apparatus according to claim 1, wherein the control unit is adapted to receive the electrical signals from the electrodes responsive to spontaneous electrical activity of the pancreatic cells.

7. Apparatus according to claim 1, wherein the control unit is adapted to analyze the signals so as to identify an aspect thereof indicative of activity of a type of cell selected from the list consisting of:

pancreatic alpha cells, pancreatic beta cells, pancreatic delta cells, and polypeptide cells, and wherein the control unit is adapted to generate the output responsive to identifying the aspect.

23. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the control unit is adapted to analyze the signals so as to identify a magnitude aspect thereof, and to generate the output responsive to identifying the magnitude aspect.

24. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the control unit is adapted to analyze the signals so as to identify a duration aspect thereof, and to generate the output responsive to identifying the duration aspect.

25. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the control unit is adapted to analyze the signals so as to identify a magnitude aspect thereof and a duration aspect thereof, wherein the control unit is adapted to analyze the aspects in combination, and wherein the control unit is adapted to generate the output responsive to analyzing the aspects.

26. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the control unit is adapted to analyze the electrical signals with respect to calibration data indicative of aspects of pancreatic electrical activity recorded at respective times, in which respective measurements of blood glucose level of the patient generated respective values.

27. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the electrodes are adapted to be placed in contact with the pancreas.

28. Apparatus according to claim 27, wherein at least one of the electrodes is adapted to be placed in contact with the head of the pancreas.

29. Apparatus according to claim 27, wherein at least one of the electrodes is adapted to be placed in contact with the body of the pancreas.

30. Apparatus according to claim 27, wherein at least one of the electrodes is adapted to be placed in contact with the tail of the pancreas.

31. Apparatus according to claim 27, wherein at least one of the electrodes is adapted to be placed in contact with a vein or artery of the pancreas.

32. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein at least one of the electrodes is adapted to be placed in contact with a blood vessel in a vicinity of the pancreas.

33. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the apparatus comprises a treatment unit, adapted to receive the output and to apply a treatment to the patient responsive to receiving the output.

34. Apparatus according to claim 33, wherein the treatment unit comprises at least one electrode in the set of electrodes, and wherein the control unit is adapted to drive the at least one electrode to apply current to the pancreas capable of treating a condition of the patient.

35. Apparatus according to claim 33, wherein the treatment unit comprises a signal-application electrode, and wherein the control unit is adapted to drive the signal-application electrode to apply current to the pancreas capable of treating a condition of the patient.

36. Apparatus according to claim 33, wherein the control unit is adapted to generate the output responsive to an aspect of the timing of the electrical signals, and wherein the treatment unit is adapted to apply the treatment responsive to the timing aspect.

37. Apparatus according to claim 33, wherein the control unit is adapted to configure the output to the treatment unit so as to be capable of modifying an amount of glucose in blood in the patient.

38. Apparatus according to claim 37, wherein the control unit is adapted to configure the output to the treatment unit so as to be capable of increasing an amount of glucose in blood in the patient.

39. Apparatus according to claim 37, wherein the control unit is adapted to configure the output so as to be capable of decreasing an amount of glucose in blood in the patient.

40. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the control unit is adapted to receive the signals from at least one of the electrodes when the at least one of the electrodes is not in contact with any islet of the pancreas.

41. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein the control unit is adapted to generate the output so as to facilitate an evaluation of a state of the patient.

82. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, wherein at least one of the electrodes has a characteristic diameter less than about 3 millimeters.

83. Apparatus according to claim 82, wherein the at least one of the electrodes has a characteristic diameter less than about 300 microns.

84. Apparatus according to claim 83, wherein the at least one of the electrodes has a characteristic diameter less than about 30 microns.

85. Apparatus according to any one of claims 1, 8, 10, 11, 13, or 14, and comprising a clip mount, coupled to at least one of the electrodes, which is adapted for securing the at least one of the electrodes to the pancreas.

8. Apparatus for monitoring a glucose level of a patient, comprising:

a set of one or more electrodes, adapted to be coupled to a pancreas of the patient; and

a control unit, adapted to receive electrical signals from the electrodes indicative of spontaneous electrical activity of pancreatic cells, to analyze the signals so as to determine a change in the glucose level, and to generate an output responsive to determining the change.

9. Apparatus according to claim 8, wherein the control unit is adapted to analyze the signals so as to identify an aspect thereof indicative of activity of a type of cell selected from the list consisting of:

pancreatic alpha cells, pancreatic beta cells, pancreatic delta cells, and polypeptide cells, and wherein the control unit is adapted to generate the output responsive to identifying the aspect.

10. Apparatus for analyzing electrical activity of a pancreas of a patient, comprising:

a set of one or more electrodes, adapted to be coupled to the pancreas; and

a control unit, adapted to receive electrical signals from the electrodes, adapted to analyze the signals so as to identify an aspect thereof which is indicative of activity of pancreatic alpha cells, and adapted to generate an output responsive to identifying the aspect.

15. Apparatus according to any one of claims 10, 11, 13, or 14, wherein the control unit is adapted to compare the aspect of the signals with a stored pattern that is indicative of activity of the cells, and to generate the output responsive thereto.

16. Apparatus according to any one of claims 10, 11, 13, or 14, wherein the control unit is adapted to analyze the signals by means of a technique selected from the list consisting of:

single value decomposition and principle component analysis, and to generate the output responsive thereto.

17. Apparatus according to any one of claims 10, 11, 13, or 14, wherein the control unit is adapted to analyze the signals under an assumption that the activity of the cells is dependent on electrical activity of another type of pancreatic cell, and to generate the output responsive thereto.

18. Apparatus according to any one of claims 10, 11, 13, or 14, wherein the control unit is adapted to analyze the signals so as to identify a frequency aspect thereof, and to generate the output responsive to identifying the frequency aspect.

19. Apparatus according to claim 18, wherein the control unit is adapted to analyze the signals so as to differentiate between a first frequency aspect of the signals which is indicative of the activity of the cells, and a second frequency aspect of the signals, different from the first frequency aspect, which is indicative of activity of another type of pancreatic cell.

20. Apparatus according to claim 18, wherein the control unit is adapted to analyze the signals so as to identify over time a change in the frequency aspect that is characteristic of the cells.

21. Apparatus according to claim 18, wherein the control unit is adapted to analyze the signals so as to identify a magnitude aspect thereof, wherein the control unit is adapted to analyze the frequency aspect and the magnitude aspect in combination, and wherein the control unit is adapted to generate the output responsive to analyzing the aspects.

22. Apparatus according to claim 18, wherein the control unit is adapted to analyze the signals so as to identify a duration aspect thereof, wherein the control unit is adapted to analyze the frequency aspect and the duration aspect in combination, and wherein the control unit is adapted to generate the output responsive to analyzing the aspects.

11. Apparatus for analyzing electrical activity of a pancreas of a patient, comprising:

a set of one or more electrodes, adapted to be coupled to the pancreas; and

a control unit, adapted to receive electrical signals from the electrodes, adapted to analyze the signals so as to identify an aspect thereof which is indicative of spontaneous activity of pancreatic beta cells, and adapted to generate an output responsive to identifying the aspect.

12. Apparatus according to claim 11, wherein the control unit is adapted to analyze the signals so as to distinguish between the aspect thereof which is indicative of the activity of the beta cells and an aspect thereof which is indicative of activity of pancreatic alpha cells, and wherein the control unit is adapted to generate the output responsive to distinguishing between the aspects.

13. Apparatus for analyzing electrical activity of a pancreas of a patient, comprising:

a set of one or more electrodes, adapted to be coupled to the pancreas; and

a control unit, adapted to receive electrical signals from the electrodes, adapted to analyze the signals so as to identify an aspect thereof which is indicative of activity of pancreatic delta cells, and adapted to generate an output responsive to identifying the aspect.

14. Apparatus for analyzing electrical activity of a pancreas of a patient, comprising:

a set of one or more electrodes, adapted to be coupled to the pancreas; and

a control unit, adapted to receive electrical signals from the electrodes, adapted to analyze the signals so as to identify an aspect thereof which is indicative of activity of polypeptide cells, and adapted to generate an output responsive to identifying the aspect.

42. A method for sensing electrical activity of a pancreas of a patient, comprising:

receiving electrical signals indicative of electrical activity of pancreatic cells which are in a plurality of islets of the pancreas; and

generating an output responsive thereto.

43. A method according to claim 42, wherein receiving the electrical signals comprises receiving an electrical signal recorded at a single site of the pancreas, which signal is indicative of electrical activity of pancreatic cells which are in two or more of the islets.

44. A method according to claim 42, wherein receiving the electrical signals comprises receiving signals indicative of electrical activity of pancreatic cells which are in five or more of the islets.

45. A method according to claim 42, wherein receiving the electrical signals comprises receiving signals indicative of electrical activity of pancreatic cells which are in ten or more of the islets.

46. A method according to claim 42, wherein receiving the electrical signals comprises:

receiving a first electrical signal recorded at a first site, indicative of electrical activity of pancreatic cells which are in a first one of the islets; and

receiving a second electrical signal recorded at a second site, indicative of electrical activity of pancreatic cells which are in a second one of the islets, which is different from the first one of the islets.

47. A method according to claim 42, wherein receiving the electrical signals comprises receiving electrical signals responsive to spontaneous electrical activity of the pancreatic cells.

48. A method according to claim 42, and comprising analyzing the signals so as to identify an aspect thereof indicative of activity of a type of cell selected from the list consisting of:

pancreatic alpha cells, pancreatic beta cells, pancreatic delta cells, and polypeptide cells, wherein generating the output comprises generating the output responsive to identifying the aspect.

64. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein analyzing the signals comprises analyzing the signals so as to identify a magnitude aspect thereof, and wherein generating the output comprises generating the output responsive to identifying the magnitude aspect.

65. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein analyzing the signals comprises analyzing the signals so as to identify a duration aspect thereof, and wherein generating the output comprises generating the output responsive to identifying the duration aspect.

66. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein analyzing the signals comprises:

analyzing the signals so as to identify a magnitude aspect thereof and a duration aspect thereof; and

analyzing the aspects in combination,

wherein generating the output comprises generating the output responsive to analyzing the aspects.

67. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein analyzing the signals comprises analyzing the electrical signals with respect to calibration data indicative of aspects of pancreatic electrical activity recorded at respective times, in which respective measurements of blood glucose level of the patient generated respective values.

68. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein receiving the electrical signals comprises receiving the signals from at least one electrode placed in contact with the pancreas.

69. A method according to claim 68, wherein receiving the electrical signals comprises receiving the signals from at least one electrode placed in contact with the head of the pancreas.

70. A method according to claim 68, wherein receiving the electrical signals comprises receiving the signals from at least one electrode placed in contact with the body of the pancreas.

71. A method according to claim 68, wherein receiving the electrical signals comprises receiving the signals from at least one electrode placed in contact with the tail of the pancreas.

72. A method according to claim 68, wherein receiving the electrical signals comprises receiving the signals from at least one electrode placed in contact with a vein or artery of the pancreas.

73. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein at least one of the electrodes is adapted to be placed in contact with a blood vessel in a vicinity of the pancreas.

74. A method according to any one of claims 42, 49, 51, 52, 54, or 55, and comprising applying a treatment to the patient responsive to receiving the output.

75. A method according to claim 74, wherein applying the treatment comprises applying electric current to the pancreas capable of treating a condition of the patient.

76. A method according to claim 74, wherein applying the treatment comprises applying the treatment responsive to an aspect of the timing of the electrical signals.

77. A method according to claim 74, wherein applying the treatment comprises configuring the treatment so as to be capable of modifying an amount of glucose in blood in the patient.

78. A method according to claim 77, wherein configuring the treatment comprises configuring the treatment so as to be capable of increasing an amount of glucose in blood in the patient.

79. A method according to claim 77, wherein configuring the treatment comprises configuring the treatment so as to be capable of decreasing an amount of glucose in blood in the patient.

80. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein receiving the signals comprises receiving the signals from at least one electrode which is not in contact with any islet of the pancreas.

81. A method according to any one of claims 42, 49, 51, 52, 54, or 55, wherein generating the output comprises facilitating an evaluation of a state of the patient.

49. A method for monitoring a glucose level of a patient, comprising:

receiving electrical signals indicative of spontaneous electrical activity of pancreatic cells;

analyzing the signals so as to determine a change in the glucose level; and

generating an output responsive to determining the change.

50. A method according to claim 49, wherein analyzing the signals comprises identifying an aspect thereof indicative of activity of a type of cell selected from the list consisting of:

pancreatic alpha cells, pancreatic beta cells, pancreatic delta cells, and polypeptide cells, and wherein generating the output comprises generating the output responsive to identifying the aspect.

51. A method for analyzing electrical activity of a pancreas of a patient, comprising:

receiving electrical signals recorded at one or more pancreatic sites;

analyzing the signals so as to identify an aspect thereof which is indicative of activity of pancreatic alpha cells; and

generating an output responsive to identifying the aspect.

56. A method according to any one of claims 51, 52, 54, or 55, wherein analyzing the signals comprises comparing the aspect of the signals with a stored pattern that is indicative of activity of the cells, and wherein generating the output comprises generating the output responsive thereto.

57. A method according to any one of claims 51, 52, 54, or 55, wherein analyzing the signals comprises analyzing the signals by means of a technique selected from the list consisting of:

single value decomposition and principle component analysis, and wherein generating the output comprises generating the output responsive thereto.

58. A method according to any one of claims 51, 52, 54, or 55, wherein analyzing the signals comprises analyzing the signals under an assumption that the activity of the cells is dependent on electrical activity of another type of pancreatic cell, and wherein generating the output comprises generating the output responsive thereto.

59. A method according to any one of claims 51, 52, 54, or 55, wherein analyzing the signals comprises analyzing the signals so as to identify a frequency aspect thereof, and wherein generating the output comprises generating the output responsive to identifying the frequency aspect.

60. A method according to claim 59, wherein analyzing the signals comprises analyzing the signals so as to differentiate between a first frequency aspect of the signals which is indicative of the activity of the cells, and a second frequency aspect of the signals, different from the first frequency aspect, which is indicative of activity of another type of pancreatic cell.

61. A method according to claim 59, wherein analyzing the signals comprises analyzing the signals so as to identify over time a change in the frequency aspect that is characteristic of the cells.

62. A method according to claim 59, wherein analyzing the signals comprises:

analyzing the signals so as to identify a magnitude aspect thereof; and

analyzing the frequency aspect and the magnitude aspect in combination,

wherein generating the output comprises generating the output responsive to analyzing the aspects.

63. A method according to claim 59, wherein analyzing the signals comprises:

analyzing the signals so as to identify a duration aspect thereof; and

analyzing the frequency aspect and the duration aspect in combination,

wherein generating the output comprises generating the output responsive to analyzing the aspects.

52. A method for analyzing electrical activity of a pancreas of a patient, comprising:

receiving electrical signals recorded at one or more pancreatic sites;

analyzing the signals so as to identify an aspect thereof which is indicative of activity of pancreatic beta cells; and

generating an output responsive to identifying the aspect.

53. A method according to claim 52, wherein analyzing the signals comprises distinguishing between the aspect thereof which is indicative of the activity of the beta cells and an aspect thereof which is indicative of activity of pancreatic alpha cells, wherein generating the output comprises generating the output responsive to distinguishing between the aspects.

54. A method for analyzing electrical activity of a pancreas of a patient, comprising:

receiving electrical signals recorded at one or more pancreatic sites;

analyzing the signals so as to identify an aspect thereof which is indicative of activity of pancreatic delta cells; and

generating an output responsive to identifying the aspect.

55. A method for analyzing electrical activity of a pancreas of a patient, comprising:

receiving electrical signals recorded at one or more pancreatic sites;

analyzing the signals so as to identify an aspect thereof which is indicative of activity of polypeptide cells; and

generating an output responsive to identifying the aspect.