Extended, controlled-release pharmaceutical compositions using charged polymers
First Claim
1. A bioadhesive pharmaceutical composition comprising an ionic treating agent and an ionic polymer, wherein the polymer is sufficiently ionized to provide bonding with the treating agent to enable the composition to release the treating agent in a controlled manner over an extended period of time, and wherein the composition does not require an emulsion system for administering the treating agent.
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Accused Products
Abstract
The present invention relates to a delivery system for pharmaceutical compositions relying in part on an ionic interaction to control and facilitate release of the treating agent. More specifically, the invention relates to an extended controlled-release system having an ionic treating agent and an ionic polymer, wherein the polymer is sufficiently ionized to release the treating agent in a controlled manner over an extended period of time and the composition does not require an emulsion system for administering the treating agent.
63 Citations
37 Claims
- 1. A bioadhesive pharmaceutical composition comprising an ionic treating agent and an ionic polymer, wherein the polymer is sufficiently ionized to provide bonding with the treating agent to enable the composition to release the treating agent in a controlled manner over an extended period of time, and wherein the composition does not require an emulsion system for administering the treating agent.
- 24. A pharmaceutical composition comprising a treating agent and a bioadhesive, water swellable, but water-insoluble cross-linked polycarboxylic acid polymer, wherein the treating agent comprises one or more of amitriptyline, amantadine, amiodarone, meclizine, diphenhydramine, hydroxyzine, atropine, lidocaine, benzocaine, procaine, buprenorphine, morphine, bromocriptine, bupropion, buspirone, butorphanol, chlorpromazine, clindamycin, clonidine, clomiphene, cyclobenzaprine, doxazosin, fentanyl, fluoxetine, leuprolide, octreotide, ondansetron, pioglitazone, oxybutynin, raloxifene, ticlopidine, or terbutaline and is released in a controlled manner over an extended period of time and wherein the composition does not require an emulsion system for administering the treating agent.
- 26. A pharmaceutical composition comprising a treating agent and a bioadhesive, water swellable, but water-insoluble cross-linked polycarboxylic acid polymer, wherein the treating agent comprises one or more of naproxen, phenobarbital, foscarnet, ganciclovir, acyclorvir, cidofovir, fanciclovir, penciclovir, fosinopril, divalproex, cefuroxime, pravastatin, rabeprazole, or warfarin and is released in a controlled manner over an extended period of time, and wherein the composition does not require an emulsion system for administering the treating agent.
- 28. A pharmaceutical composition for treating or preventing pelvic pain, or for treating or improving infertility, associated with uterine dysrhythmia comprising a therapeutically effective amount of an ionic, anti-dysrhythmic treating agent and a bioadhesive, water swellable, but water-insoluble cross-linked polycarboxylic acid polymer, such that the treating agent is released in a controlled manner over an extended period of time, and wherein the composition does not require an emulsion system for administering the treating agent.
- 30. A method of treating or preventing a disease or condition in a mammal comprising administering a composition that comprises a therapeutically effective amount of an ionic treating agent and an ionic polymer, wherein the polymer is sufficiently ionized to provide bonding with the treating agent, the treating agent is released in a controlled manner over an extended period of time through the chemical bonding with the polymer, and the composition does not require an emulsion system for administering the treating agent.
- 36. A method of treating or preventing pelvic pain, or for treating or improving infertility, comprising vaginally administering a composition that comprises a therapeutically effective amount of an ionic, anti-dysrhythmic treating agent and a bioadhesive, water swellable, but water-insoluble cross-linked polycarboxylic acid polymer, wherein the treating agent is released in a controlled manner over an extended period of time, and wherein the composition does not require an emulsion system for administering the treating agent.
Specification