Ultra-fast nucleic acid sequencing device and a method for making and using the same
First Claim
1. A system for detecting at least one polymer, comprising:
- at least one semiconductor device having at least one detecting region, adapted to detect a charge representative of a component of said polymer proximate to said detecting region.
2 Assignments
0 Petitions
Accused Products
Abstract
A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or opening therein, for detecting a charge representative of a component of a polymer, such as a nucleic acid strand, proximate to the detecting region, and a method for manufacturing such a semiconductor device. The system and method can thus be used for sequencing individual nucleotides or bases of ribonucleic acid (RNA) or deoxyribonucleic acid (DNA). The semiconductor device includes at least two doped regions, such as two n-typed regions implanted in a p-typed semiconductor layer or two p-typed regions implanted in an n-typed semiconductor layer. The detecting region permits a current to pass between the two doped regions in response to the presence of the component of the polymer, such as a base of a DNA or RNA strand. The current has characteristics representative of the component of the polymer, such as characteristics representative of the detected base of the DNA or RNA strand.
245 Citations
55 Claims
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1. A system for detecting at least one polymer, comprising:
at least one semiconductor device having at least one detecting region, adapted to detect a charge representative of a component of said polymer proximate to said detecting region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 33, 34, 35, 36, 37)
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12. A method for detecting at least one polymer, comprising the steps of:
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positioning a portion of said polymer proximate to a detecting region of at least one semiconductor device; and
at said detecting region, detecting a charge representative of a component of said polymer proximate to said detecting region. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A method for manufacturing a device for detecting a polymer, comprising the steps of:
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providing a semiconductor structure comprising at least one semiconductor layer; and
creating a detecting region in said semiconductor structure, said detecting region being adapted to detect a charge representative of a component of said polymer proximate to said detecting region. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 38, 39, 40)
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41. A system for detecting at least one polymer, comprising:
at least one structure comprising an insulating layer and at least one metal layer, arranged to form at least one detecting region adapted to detect a charge representative of a component of said polymer proximate to said detecting region. - View Dependent Claims (42, 43, 44, 45, 46, 47)
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48. A method for manufacturing a device for detecting a polymer, comprising the steps of:
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providing a structure comprising an insulating layer and at least one metal layer; and
creating a detecting region in said structure, said detecting region being adapted to detect a charge representative of a component of said polymer proximate to said detecting region. - View Dependent Claims (49, 50, 51, 52)
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53. A system for detecting at least one polymer, comprising:
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a plurality of detecting devices, each having at least one detecting region, adapted to detect a charge representative of a component of said polymer proximate to said detecting region; and
a reader, adapted to selectably obtain a respective reading from each of said detecting devices, said respective readings representing respective charges detected by said detecting devices. - View Dependent Claims (54, 55)
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Specification