Polypeptides containing gamma-amino acids
First Claim
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1. An unnatural polypeptide compound selected from the group consisting of:
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Abstract
Disclosed are polypeptide compounds containing at least one residue comprising a cyclically-constrained γ-amino acid residue. The compounds have the formula
where A is a hydrogen, hydroxy, amino- or carboxy-protecting group, Y is a single bond or a prolyl-containing linking group, and X and Y are γ-amino acid residues, provided that one of X or Y is a conformationally-restrained γ-amino acid residue, and “a,” “c,” and “d” are positive integers. The compounds find use as non-enzymatically degradable probes to mimic protein behavior in solution.
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26 Claims
- 1. An unnatural polypeptide compound selected from the group consisting of:
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