Composition and method for growing, protecting, and healing tissues and cells

• US 20030212005A1
• Filed: 06/10/2003
• Published: 11/13/2003
• Est. Priority Date: 03/24/1998
• Status: Abandoned Application

• Current Assignee: Anita M. Petito, George D. Petito
• Original Assignee: Anita M. Petito, George D. Petito
• Inventors: Petito, George D., Petito, Anita M.
• Application Number:
  US10/457,599
• Publication Number:
  US 20030212005A1
• Time in Patent Office: Days
• US Class Current: 514/21
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/39 Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
• CPC Class Codes: A61L 15/225 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

A method and medicinal compositions for facilitating the growth, protection and healing of tissues and cells in animals and humans. The compositions are formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof

Claims

1. A medicinal composition for promoting tissue and cell growth, protecting cells and tissues, reducing scar tissue and repairing damaged animal tissues, comprising a therapeutically effective amount of hydrolyzed collagen, said composition being administered in a pharmaceutically acceptable form selected from the group consisting of a powder, a gel, a paste, a foam, a film, a sponge, a capsule, a tablet, a chewing gum, a patch, a liquid, and a paste.

2. The medicinal composition according to claim 1, wherein said hydrolyzed collagen is combined with at least one therapeutic agent selected from the group consisting of hyaluronic acid, a hyaluronic acid salt, a polysulfated glycosaminoglycan, and a glucosamine salt, the hydrolyzed collagen serving as a pharmaceutical carrier for said at least one therapeutic agent.

3. The medicinal composition according to claim 2, wherein said at least one therapeutic agent is hyaluronic acid.

4. The medicinal composition according to claim 2, wherein said at least one therapeutic agent is a polysulfated glycosaminoglycan.

5. The medicinal composition according to claim 4, wherein said polysulfated glycosaminoglycan is chondroitin sulfate.

6. The medicinal composition according to claim 2, wherein said at least one therapeutic agent is a mixture of hyaluronic acid and a polysulfated glycosaminoglycan.

7. The medicinal composition according to claim 3, wherein said hydrolyzed collagen and said hyaluronic acid are in powdered form.

8. The medicinal composition according to claim 3, wherein said hyaluronic acid is in a solution.

9. The medicinal composition according to claim 1, wherein said pharmaceutically acceptable form is a powder.

10. The medicinal composition according to claim 9, having a moisture content of approximately 2-10 wt. %, a pH range of 5.5-6.5, an ash content of less than 2.5 wt. % and an isotonic point of 5.0-6.5.

11. The medicinal composition according to claim 1, wherein said a pharmaceutically acceptable form is a gel.

12. The medicinal composition according to claim 11, wherein said gel comprises about 40-75 wt. % hydrolyzed Type I collagen and about 20-95 vol. % water.

13. The medicinal composition according to claim 12, wherein said gel comprises about 60 wt. % hydrolyzed Type I collagen.

14. The medicinal composition according to claim 11, wherein said gel further includes an antimicrobial compound for dental applications.

15. The medicinal composition according to claim 14, wherein said antimicrobial compound is selected from the group consisting of chlorohexadine gluconate and parachloro-metaxylenol.

16. The medicinal composition according to claim 14, wherein said gel further includes an analgesic agent.

17. The medicinal composition according to claim 16, wherein said analgesic agent is benzocaine.

18. The medicinal composition according to claim 1, wherein said a pharmaceutically acceptable form is a film.

19. The medicinal composition according to claim 18, further including a cross-linking agent.

20. The medicinal composition according to claim 19, wherein said cross-linking agent is selected from the group consisting of humectant, propylene glycol, sorbitol, and glycerine.

21. The medicinal composition according to claim 18, further including a preservative.

22. The medicinal composition according to claim 21, wherein said preservative is selected from the group consisting of benzyl alcohol and paraben.

23. The medicinal composition according to claim 1, further including an antibiotic.

24. The medicinal composition according to claim 23, wherein said antibiotic is selected from the group consisting of tetracycline, streptomycin, and cephalosporin.

25. The medicinal composition according to claim 1, further including an antibacterial.

26. The medicinal composition according to claim 25, wherein said antibacterial is selected from the group consisting of iodine, parachlorometaxylenol, chlorhexidine gluconate and chlorhexidine acetate.

27. A method for promoting tissue and cell growth, protecting cells and tissues, reducing scar tissue and repairing damaged animal tissues, comprising administering to a person in need thereof a therapeutically effective amount of the composition according to claim 1.

28. A method for promoting tissue and cell growth, protecting cells and tissues, reducing scar tissue and repairing damaged animal tissues, comprising administering to a person in need thereof a therapeutically effective amount of the composition according to claim 2.