Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
First Claim
1. A conjugate, comprising a targeted agent and a chemokine receptor targeting agent, or a portion thereof, wherein the conjugate binds to a receptor resulting in internalization of the linked targeted agent in cells bearing the receptor, wherein the receptor is selected from the group consisting of CXCR4, CCR2b, CCR3, CCR5, CCR6, CCR8 and CX3CR1.
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Accused Products
Abstract
Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agents, such as chemokines, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, proliferation and migration of immune effector cells, including leukocyte cell types, neutrophils, macrophages, and eosinophils.
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Citations
37 Claims
- 1. A conjugate, comprising a targeted agent and a chemokine receptor targeting agent, or a portion thereof, wherein the conjugate binds to a receptor resulting in internalization of the linked targeted agent in cells bearing the receptor, wherein the receptor is selected from the group consisting of CXCR4, CCR2b, CCR3, CCR5, CCR6, CCR8 and CX3CR1.
- 26. The conjugate of 24, wherein the chemical linker is a heterobifunctional cleavable cross-linker.
Specification