Undesignated allogeneic stem cell bank

• US 20030215942A1
• Filed: 02/13/2003
• Published: 11/20/2003
• Est. Priority Date: 02/14/2002
• Status: Abandoned Application

• Current Assignee: Stemcyte Inc
• Original Assignee: Stemcyte Inc
• Inventors: Punzalan, Rubio R., Petz, Lawrence D., Chow, Robert, Rodgerson, Denis O.
• Application Number:
  US10/367,339
• Publication Number:
  US 20030215942A1
• Time in Patent Office: Days
• US Class Current: 435/366
• CPC Class Codes: A61K 35/16 Blood plasma; Blood serum umbilical cord blood A61K35/51
• CPC Class Codes: A61K 35/28 Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• CPC Class Codes: A61K 35/50 Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
• CPC Class Codes: G16H 50/80 for detecting, monitoring or modelling epidemics or pandemics, e.g. flu

Abstract

This invention provides methods for supplying a therapy for individuals exposed to radiation following a nuclear event, through the prospective establishment of an undesignated allogeneic stem cell bank with prospective HLA typing of healthy potential recipients.

Claims

1. A method for providing a stem cell unit in an allogeneic stem cell bank for a potential recipient, said method comprising:

(i) providing a plurality of stem cell units having been typed to form an allogeneic stem cell bank having a plurality of typed stem cell units;

(ii) providing a record for each of said plurality of typed stem cell units;

(iii) providing typing for a potential recipient, said potential recipient having a type identifier;

(iv) storing said record for each of said plurality of typed stem cell units and said type identifier in a database;

(v) comparing said type identifier with said record for each of said plurality of typed stem cell units to find a matched stem cell unit; and

(vi) storing said matched stem cell unit in said database for said potential recipient'"'"'s use, thereby providing said stem cell unit for said potential recipient.

2. The method of claim 1, wherein said potential recipient is a plurality of recipients.

3. The method of claim 1, further comprising treating said potential recipient with said matched stem cell unit.

4. The method of claim 3, wherein said potential recipient has been exposed to a lethal dose of radiation.

5. The method of claim 4, wherein treatment of said recipient with said matched stem cell unit occurs immediately after exposure.

6. The method of claim 2, wherein said plurality of recipients have been exposed to a lethal dose of radiation.

7. The method of claim 1, wherein said plurality of stem cell units comprise hematopoietic and non-hematopoietic stem cells.

8. The method of claim 7, wherein each of said plurality of stem cell units comprise hematopoietic stem cells.

9. The method of claim 8, wherein said hematopoietic stem cells comprise long-term hematopoietic stem cells.

10. The method of claim 8, wherein said hematopoietic stem cells are obtained from bone marrow.

11. The method of claim 8, wherein said hematopoietic stem cells are obtained from peripheral blood.

12. The method of claim 8, wherein said hematopoietic stem cells are obtained from umbilical cord blood.

13. The method of claim 8, wherein said hematopoietic stem cells are obtained from placental blood.

14. The method of claim 1, wherein said each of said plurality of stem cell units are cryogenically preserved.

15. The method of claim 7, wherein each of said plurality of stem cell units comprise non hematopoietic stem cells.

16. The method of claim 15, wherein each of said non-hematopoietic stem cells are capable of converting to hematopoietic stem cells.

17. The method of claim 15, wherein each of said non-hematopoietic stem cells comprise adult stem cells.

18. The method of claim 15, wherein each of said non-hematopoietic stem cells comprise embryonic stem cells.

19. The method of claim 1, wherein said allogeneic stem cell bank is protected against a nuclear attack.

20. A method for supplying a stem cell unit to an individual exposed to radiation following a nuclear event, said method comprising:

establishing an undesignated radiation protected allogeneic stem cell bank with prospective HLA typing of healthy potential recipients, thereby supplying a stem cell unit to an individual exposed to radiation following a nuclear event.

21. A computer-readable medium or combination of computer-readable media, containing a program for maintaining type information and providing a matched a stem cell unit for a potential recipient, said program comprising code to effect:

(i) providing a record of typed stem cell units in an allogeneic stem cell bank;

(ii) providing a type identifier for a potential recipient;

(iii) storing said type identifier and said record of typed stem cell units;

(iv) comparing said type identifier with said record of typed stem cell units to find a matched stem cell unit; and

(v) storing said matched stem cell unit for said potential recipient'"'"'s use.

22. The medium or media of claim 21, wherein media or medium are selected from the group consisting of a RAM, a ROM, a disk, an ASIC, and a PROM.