Measurement site dependent data preprocessing method for robust calibration and prediction
First Claim
1. A method for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising the steps of:
- collecting a sample measurement which is a response signal from said body to which a probing signal is applied;
transforming said sample measurement by applying a basis set to said sample measurement, said basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
calibrating said transformed sample measurement by applying a calibration model; and
determining a noninvasive measurement of said target analyte.
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Abstract
A solution for reducing interference in noninvasive spectroscopic measurements of tissue and blood analytes is provided. By applying a basis set representing various tissue components to a collected sample measurement, measurement interferences resulting from the heterogeneity of tissue, sampling site differences, patient-to-patient variation, physiological variation, and instrumental differences are reduced. Consequently, the transformed sample measurements are more suitable for developing calibrations that are robust with respect to sample-to-sample variation, variation through time, and instrument related differences. In the calibration phase, data associated with a particular tissue sample site is corrected using a selected subset of data within the same data set. This method reduces the complexity of the data and reduces the intra-subject, inter-subject, and inter-instrument variations by removing interference specific to the respective data subset. In the measurement phase, the basis set correction is applied using a minimal number of initial samples collected from the sample site(s) where future samples will be collected.
82 Citations
102 Claims
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1. A method for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising the steps of:
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collecting a sample measurement which is a response signal from said body to which a probing signal is applied;
transforming said sample measurement by applying a basis set to said sample measurement, said basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
calibrating said transformed sample measurement by applying a calibration model; and
determining a noninvasive measurement of said target analyte. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. An apparatus for noninvasively measuring a target analyte in a body using spectroscopic analysis, comprising:
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means for transmitting a probe signal into said body;
means for detecting said signal responded from said body; and
means for converting said detected signal into a sample measurement of said analyte;
wherein said means for converting is operable to;
transform said sample measurement by applying a basis set thereto, said basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
apply a calibration model to said transformed sample measurement; and
display a noninvasive measurement of said target analyte. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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69. A computer usable medium containing instructions in computer readable form for carrying out a method for noninvasively measuring a target analyte in a body using spectroscopic analysis, said method comprising the steps of:
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collecting a sample measurement which is a response signal from said body to which a probing signal is applied;
transforming said sample measurement by applying a basis set to said sample measurement, said basis set including at least one interfering component, wherein any interference in said sample measurement corresponding to said at least one interfering component in said basis set is removed;
calibrating said transformed sample measurement by applying a calibration model; and
determining a noninvasive measurement of said target analyte. - View Dependent Claims (70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102)
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Specification