Registration of thoracic and abdominal imaging modalities

• US 20030216631A1
• Filed: 04/01/2003
• Published: 11/20/2003
• Est. Priority Date: 04/03/2002
• Status: Active Grant

• Current Assignee: Segami S.A.R.L.
• Original Assignee: Segami S.A.R.L.
• Inventors: Delso, Gaspar, Rey, Oscar Camara, Bloch, Isabelle
• Granted Patent: US 7,397,934 B2
• Time in Patent Office: Days
• US Class Current: 600/407
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: G06T 2207/30061 Lung
• CPC Class Codes: G06T 3/153 using elastic snapping
• CPC Class Codes: G06T 7/33 using feature-based methods
• CPC Class Codes: G06T 7/35 using statistical methods

Abstract

This disclosure presents an improved method for registering anatomical medical images and functional medical images. The example deals with the registration of x-ray computer tomography images with positron emission tomography images. The process is characterized by clinically useful registration with minimal computer calculations and minimal delay for computation. A nonrigid B-Spline free form deformation is used in both a preliminary coarse registration and the finished fine registration. Additional steps are used to insure accurate and complete registrations.

Claims

1. The process of registering an anatomical image of the thorax and abdomen of a patient with a functional image of the thorax and abdomen of the patient comprising the steps:

a. obtaining an anatomical image of the thorax and abdomen of the patient,

b. obtaining a functional image of the thorax and abdomen of the patient, the functional image containing functional and anatomical features,

c. extracting the anatomical features of the anatomical and functional images,

d. registering the anatomical and functional images by a process comprising the step;

1. transforming the scans using nonrigid B-Spline free form deformations using the anatomical features extracted from the anatomical and functional images.

2. The process of claim 1 further comprising the step following step d.1:

2. maximizing the information from one image contained in the other image using normalized mutual information.

3. The process of registering an anatomical image of the thorax and abdomen of a patient with a functional image of the thorax and abdomen of the patient comprising the steps:

a. obtaining an anatomical image of the thorax and abdomen of the patient,

b. obtaining a functional image of the thorax and abdomen of the patient, the functional image containing functional and anatomical features,

c. extracting the anatomical features of the anatomical and functional images,

d. coarse registering the anatomical and functional images by a process comprising the steps;

1. transforming the scans using nonrigid B-Spline free form deformations using the anatomical features extracted from the anatomical and functional images,

2. minimizing the root mean square difference of corresponding pixel gray levels of the transformed scans and the segmented anatomical features, and

3. minimizing the gradient descent of the positions of all the control points,

e. fine registering the anatomical and functional images comprising the steps;

1. transforming the results of step d. and the functional scan using nonrigid B-Spline free form deformations,

2. maximizing the information from one image contained in the other image using normalized mutual information and the results of step e. 1. and the anatomical scan, and

3. minimizing the gradient descent of the position of all the control points, and

f. displaying the registered anatomical and functional images.

4. The process of claim 3 wherein the anatomical image is a computer tomography scan.

5. The process of claim 3 wherein the functional image is a positron emission tomography scan.

6. The process of claim 3 wherein the anatomical image is a nuclear magnetic resonance scan.

7. The process of claim 3 wherein the anatomical image is an ultrasound scan.

8. The process of claim 3 wherein the anatomical features segmented are the skin, lungs, skeleton, kidney, or liver.

9. The process of claim 3 wherein the steps of step d. are repeated.

10. The process of claim 3 wherein the steps of step e. are repeated.

11. The process of claim 3 wherein step e. 2. is omitted and replaced by the following step:

e. 2A. maximizing the information from one image contained in the other image using Parzen windows and the results of step e. 1. and the anatomical scan, and,