Bayesian discriminator for rapidly detecting arrhythmias

• US 20030216654A1
• Filed: 05/07/2002
• Published: 11/20/2003
• Est. Priority Date: 05/07/2002
• Status: Abandoned Application

• Current Assignee: City University of Hong Kong
• Original Assignee: City University of Hong Kong
• Inventors: Tse, Hung-Fat, Xu, Weichao, Lau, Chu-pak, Chan, Francis Hy, Fung, Peter Chin Wan
• Application Number:
  US10/141,104
• Publication Number:
  US 20030216654A1
• Time in Patent Office: Days
• US Class Current: 600/509
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61B 5/7267 involving training the classification device
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

A method for accurate and rapid automated detection of atrial fibrillation (AF), sinus rhythm (SF), and atrial flutter (AFL) is disclosed, which allows distinguishing of these cardiac signals with lowered risk of errors by implanted pacemakers and like devices. The method includes training episodes of intra-cardiac signals (called the closed data set CDS) to evaluate five feature parameters with a discriminator classifying the signal into AF, AFL or sinus rhythm (SR). Comparison with the independent decisions of experienced physicians for each episode reveals specificity, accuracy and sensitivity of greater than 97%. Each episode is a window of intracardiac signal of interval 1-2 seconds with the discriminator providing results in less than 0.25 s. In another aspect, the method is resistant to the presence of noise in the data. In yet another aspect, more feature parameters may be used in alternative implementations including for detecting signals other than AF, AFL & SR.

Claims

1. A method for detecting a sinus rhythm of interest with aid of a computer executable instructions processing device based on electrophysiological information obtained from a subject via sensors coupled to the subject, comprising the steps of:

inputting a training data set as open-test data set of intra-atrial electrograms for evaluation, and

receiving a result in accordance with a set of estimated conditional probabilities of the sinus rhythm and a plurality of features.

2. A method according to claim 1 further comprising the steps of:

selecting the plurality of features of intra-atrial electrograms and a type of output,

inputting a new episode as close-test data set of intra-atrial electrograms for training, and

estimating the set of conditional probabilities for the plurality of features and the type of output in accordance with a multiple-index Bayesian discriminator algorithm from the close-test data set.

3. A method according to claim 2 further comprising the step of selecting additional features for estimating conditional probabilities.

4. A method according to claim 1 further comprising the step of modifying at least one estimated conditional probability from the set of estimated conditional probabilities with the open-test data set and the result.

5. A method according to claim 1 further comprising the step of diagnosing heart conditions in accordance with the result.

6. A method according to claim 2 further comprising the step of selecting a treatment to the subject corresponding to the result.

7. A method according to claim 2, wherein the plurality of features is selected from the group consisting of regularity, rate, energy distribution, percent time of quiet interval, and number of baseline reaching.

8. A method according to claim 2, wherein the type of output is selected from the group consisting of sinus rhythm, atrial flutter, and atrial fibrillation.

9. A method according to claim 2 further comprising the step of generating the result in less than five (5) seconds from receiving the open-test data set.

10. A device for providing an electrical signal in response to detecting a predetermined sinus rhythm with the aid of a set of computer executable instructions based on electrophysiological information obtained from sensors, for example, the device may comprise:

a set of power input terminals;

a data module for providing conditional probabilities of the predetermined sinus rhythm relative to a plurality of features;

an input for receiving electrophysiological information;

a member for providing the electrical signal for a modulating effect on heartbeats; and

at least one computer executable instructions processing unit.

11. The device of claim 10 wherein the predetermined sinus rhythm is selected from the group consisting of sinus rhythm, atrial flutter, and atrial fibrillation.

12. The device of claim 10 further comprising a module for identifying at least one feature from the group consisting of regularity, rate, energy distribution, percent time of quiet interval, and number of baseline reaching in the electrophysiological information.

13. The device of claim 10 further comprising a module or modules for updating a conditional probability of the predetermined sinus rhythm with the electrophysiological information.

14. The device of claim 10 wherein the electrical signal provided by the member belongs to the group consisting of the electrical signal or input to the chest wall that synchronizes the heart and allows the normal rhythm to restart, small electrical impulses to the heart muscle to maintain a suitable heart rate, electrical energy to the heart muscle to cause the heart to beat in a normal rhythm, and high radio-frequency energy through a special catheter to small areas of tissues that may be related to abnormal heart rhythms.

15. A computer readable media carrying thereon computer executable instructions for carrying out the steps of a method for detecting a sinus rhythm of interest based on electrophysiological information obtained from a subject via sensors coupled to the subject, the method comprising the steps of:

inputting an open-test data set of intra-atrial electrograms for evaluation, and

receiving a result in accordance with a set of estimated conditional probabilities of the sinus rhythm and a plurality of features.

16. The computer readable media of claim 15 further comprising computer executable instructions for carrying out the steps of:

selecting the plurality of features of intra-atrial electrograms and a type of output,

inputting a close-test data set of intra-atrial electrograms for training, and

estimating the set of conditional probabilities for the plurality of features and the type of output in accordance with a multiple-index Bayesian discriminator algorithm from the close-test data set.

17. The computer readable media of claim 16 further comprising computer executable instructions for carrying out the step of selecting additional features for estimating conditional probabilities.

18. The computer readable media of claim 15 further comprising computer executable instructions for carrying out the step of modifying at least one estimated conditional probability from the set of estimated conditional probabilities with the open-test data set and the result.

19. The computer readable media of claim 15 further comprising computer executable instructions for carrying out the step of diagnosing heart conditions in accordance with the result.

20. The computer readable media of claim 16 further comprising computer executable instructions for carrying out the step of providing a treatment to the subject corresponding to the result.

21. The computer readable media of claim 16 further comprising computer executable instructions wherein the plurality of features is selected from the group consisting of features such as regularity, rate, energy distribution, percent time of quiet interval, and number of baseline reaching.

22. The computer readable media of claim 16 further comprising computer executable instructions wherein the type of output is selected from the group consisting of sinus rhythm, atrial flutter, and atrial fibrillation.

23. The computer readable media of claim 16 further comprising computer executable instructions for carrying out the step of generating the result preferably in less than five (5) seconds from receiving the open-test data set.