Apparatus and method for high energy photodynamic therapy of acne vulgaris, seborrhea and other skin disorders

• US 20030216795A1
• Filed: 02/13/2003
• Published: 11/20/2003
• Est. Priority Date: 07/07/1999
• Status: Abandoned Application

• Current Assignee: Cure-Light Ltd.
• Original Assignee: Cure-Light Ltd.
• Inventors: Harth, Yoram, Korman, Avner
• Application Number:
  US10/366,452
• Publication Number:
  US 20030216795A1
• Time in Patent Office: Days
• US Class Current: 607/88
• CPC Class Codes: A61K 41/0071 PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
• CPC Class Codes: A61N 2005/0642 Irradiating part of the body at a certain distance
• CPC Class Codes: A61N 5/0616 Skin treatment other than tanning
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

An apparatus, a device, a system and a method for the phototherapy of different skin disorders including acne vulgaris, seborrhea and inflammation. The invention includes a multiple session treatment method by a high irradiance violet/blue CW time gated, or pulsed, light source with a spectral emission in the range of 400-450 nanometer and possible additional spectral bands in the green and red part of the spectrum. The apparatus includes at least one narrow spectral band light source with spectral emittance concentrated in the violet/blue spectral band. The invention can reduce the level of extra cellular pro inflammatory cytokines related to inflammation as well as to significantly reduce the acne bacteria population by a photodynamic effect. A system for the treatment of acne lesions combining the apparatus for the eradication of P. acne bacteria and the acne affected area inflammation and a device for the elimination of the red spots around the acne lesions using intense pulsed light in the spectral band 500-1000 nm.

Claims

1. An apparatus for treatment of a skin disorder and conditions and symptoms associated therewith, the apparatus comprising:

(a) at least one light source with spectral emittance concentrated in at least one specific narrow spectral band, wherein one spectral band is in the range of 400 to 450 nm radiating energy fluence of at least 5 J/cm² per a single light exposure; and

(b) an optical system for collecting and shaping light emitted from said at least one light source; and

(c) an electronic unit to control parameters associated with said spectral emittance from said at least one light source.

2. The apparatus of claim 1, wherein an illumination energy of said light source flux, is higher than a predetermined threshold level required for biological destruction of the skin disorder causing factors.

3. The apparatus of claim 1, wherein said light source is an intense pulse light generating source.

4. The apparatus of claim 1, wherein said light source is a time gated high energy CW light source.

5. The apparatus as in claim 1, wherein the skin disorder is caused by p. acne bacteria and said threshold level is a level required for biological destruction of P. acne bacteria at a rate faster than the rate of proliferation.

6. The apparatus of claim 2, wherein said illumination energy threshold level of said illumination light source on a treated skin area is at least 40 mw/cm² for at least 10 minutes and at least 28 Joule/cm² 11.

7. The apparatus of claim 2, wherein said illumination energy threshold level is a level facilitated by a high energy output of a non coherent illumination source;

and wherein said illumination source is any combination of radiation sources selected from the group including at least a gas discharge metal halide lamp, a gas discharge xenon lamp, a gas discharge xenon and rare metals combination lamp, an excimer lamp, a LED diode matrix and a diode laser matrix.

8. The apparatus of claim 1, wherein an illuminated area on a patient body by said light source comprises an illumination area large enough to illuminate an infected typical size skin area from a fixed position of said light source related to said skin area.

9. The apparatus of claim 8, wherein the illuminated area on a patient body by said light source is characterized by an energy flux that is above said threshold level and that is large enough in its dimensions to cover and treat in a single exposure session an entire human body part and an entire infected skin area from at least a single fixed position of said light source related to said organ and skin area.

10. The apparatus of claim 1, further comprising:

a computer controlled imaging unit for imaging an illuminated treated area and for monitoring by counting lesions on said treated area, using computerized counting techniques.

11. The apparatus of claim 1, further comprising:

at least one optical element of a group comprising a liquid filled light guide, a solid transparent light guide, a fiber bundle light guide and an array of lenses and mirrors for collecting and conducting the said light source radiation and illuminating the skin treated area at an adjustable distance, energy density and direction.

12. The apparatus of claim 1, wherein said at least one light source is selected from the group including a Gallium, Mercury, xenon and halides gas mixture discharge lamp with peak emission in the 400-450 spectral band, an Excimer lamp with peak emission in the 400-450 spectral band, an Ion Krypton gas laser with a spectral emission in the range 405 to 440 nm, and a diode, wherein said diode is selected from the group consisting of violet/blue laser diodes, and light emitting diodes (LED) with narrow spectral band emission in the range 405-440 nm, or any combination thereof.

19. The apparatus according to claim 4, wherein said treatment comprises treatment of inflammation.

13. A method of treating a skin disorder, comprising:

providing a light radiation source having spectral characteristics of at least one of a group of narrow spectral bands consisting of violet/blue (400-450 nm), red (630-670 nm) and green (520-550 nm) light said light source having energy output flux over a predetermined threshold level;

illuminating said skin area with said light radiation source;

additionally illuminating said skin area after a predetermined time period.

14. The method of claim 13, wherein said threshold level is above 5 J/cm².

15. A method according to claim 13, wherein said predetermined time period is at least 24 hours.

16. The method according to claim 13, wherein said skin disorder is selected from the group consisting of acne, seborrhea, soft tissue inflammation, muscular inflammation, post traumatic soft tissue and muscular pain, arthralgia, skin ulcers, contact dermatitis, atopic dermatitis and scleroderma, and conditions and symptoms thereof.

17. The method according to claim 13, wherein said time interval is 1-5 weekly exposures to violet/blue light for typically 2-10 weeks, with a minimum 24 hour'"'"'s time gap between exposures.

18. The method of claim 13 comprising an intense pulsed light generating source.

20. The method according to claim 13, wherein treated area is larger than 2 cm×

2 cm.

21. A system for the combined treatment of acne inflammatory lesions and for the reduction of the lesion localized redness the system comprising:

(a) a first treatment device for destroying the P. acne bacteria by a violet/blue light exposure; and

(b) a second treatment device for selectively destroying small diameter blood vessels contained at a selected depth and in selected areas of a patient'"'"'s dermis preferably in the vicinity of the acne lesion.

22. The treatment system of claim 21 wherein at least one of the first and second treatment devices comprises an intense pulse light source.

23. The treatment system of claim 21 wherein the pulsed light source has at least one spectral band between 450 nm to 800 nm, wherein;

(a) each light pulse delivering a fluence at the epidermis surface being treated of between 3 J/cm². and 6 J/cm²;

(b) each pulse having a pulse duration of between 0.2 milliseconds and 2 millisecond;

(c) the exposed skin surface area may be between 0.01 square centimeters and 0.3 square centimeters;

(d) the pulsed light source delivering a single pulse, or a multiple of pulses; and

(e) the light source being selected from the group consisting of a first light source that is continuous-wave light source with pulse duration being controlled by gating the light source to provide a long pulse light and a second light source that is a slow repetition rate narrow pulse source with rate in the range of 0.3 to 2 Hz.